Behavioral sensitivity to LSD: Dependency upon the pattern of central 5HT depletion
James A. Joseph, James B. Appel
Pharmacology Biochemistry and Behavior May 1, 1977 DOI: 10.1016/0091-3057(77)90108-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | p-chloroamphetamine 5 7-dihydroxytryptamine p-chlorophenylalanine LSD |
| Dose | 0.02 mg/kg |
| Duration | 12 days after 5,7-DHT administration |
| Topics | Serotonin LSD |
| Keywords | 5,7-dihydroxytryptamine 5-HT Receptor P-chloroamphetamine Sensitivity control systems Endocrinology Pharmacology |
| Citations | 18 |
| Key findings | Only 5,7-dihydroxytryptamine, not p-chloroamphetamine, increased sensitivity to a low dose of LSD, disrupting bar-press behavior, suggesting a specific pattern of serotonin depletion is required. |
Abstract
Two experiments were carried out using a fixed ratio (FR) schedule of water reinforcement to determine the efficacy of two serotonin (5HT) depleting agents (p-chloroamphetamine, 5, 7-dihydroxytryptamine) in altering sensitivity to a low dose of LSD (0.02 MG/KG). The results showed that while both p-chloroamphetamine (PCA) and 5, 7 dihydroxytryptamine (5, 7 DHT) were efficacious in reducing whole brain 5HT, only 5, 7 DHT altered LSD sensitivity such that a 0.02 mg/kg dose of LSD given 12 days after 5, 7 DHT administration disrupted bar press behavior. This was not observed in animals given PCA within similar parameters. Moreover, 4 animals given PCA that did not show increased sensitivity to LSD, did show behavioral disruption to LSD (0.02 mg/kg when they were pretreated with p-chlorophenylalanine, Results are discussed on terms of a possible particular pattern of 5HT depletion that must be achieved before sensitivity to LSD is observed.