Effect of Epinephrine on Adrenal Ascorbic Acid Following Premedication With Lysergic Acid Diethylamides or 5-Hydroxyindolalkylamines
E. Costa, G. Zetler
Experimental Biology and Medicine June 1, 1958 DOI: 10.3181/00379727-98-24006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Rats and cats |
| Interventions | LSD BOL serotonin bufotenin epinephrine |
| Dose | LSD 10 γ/kg i.p.; BOL 40 γ/kg i.p.; serotonin 30 γ/kg i.p. and 88.01 γ/kg i.v.; bufotenin 30 γ/kg i.p. and 4.82 γ/kg i.v.; epinephrine 25 γ/kg i.p. |
| Topics | LSD |
| Citations | 7 |
| Key points | LSD (10 γ/kg), serotonin (30 γ/kg), and bufotenin (30 γ/kg) each increased epinephrine-induced adrenal ascorbic acid depletion in rats, whereas BOL (40 γ/kg) did not. In cats, bufotenin enhanced epinephrine-induced nictitating membrane contractions at a lower intravenous threshold dose (4.82 γ/kg) than serotonin (88.01 γ/kg). |
Abstract
10 γ/kg i.p. of LSD potentiate the adrenal ascorbic acid depletion caused in rats by 25 γ/kg i.p. of epinephrine, 40 γ/kg i.p. of BOL are ineffective in this respect. 30 γ/kg i.p. of both serotonin and bufotenin potentiate the effects of epinephrine (25 γ/kg i.p.). The threshold doses of bufotenin and serotonin enhancing the epinephrine induced contractions of cat's nictitating membrane were 4.82 γ/kg i.v. and 88.01 γ/kg i.v.