Effects on homeostasis of 5-hydroxytryptamine, lysergic acid diethylamide and 2-brom-d-lysergic acid
J. Paul Mcneill, John K. Hampton
American Journal of Physiology-Legacy Content December 1, 1959 DOI: 10.1152/ajplegacy.1959.197.6.1191 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-HT LSD BOL 5-HT + LSD 5-HT + BOL |
| Topics | LSD |
| Citations | 3 |
| Key findings | Intramuscular injection of 5-HT produces a multiphasic mortality curve after trauma, while intravenous administration of 5-HT, LSD, or BOL alone does not significantly alter mortality, but an equimolar combination of 5-HT and LSD given intravenously significantly increases mortality. |
Abstract
Rats were injected intramuscularly with 5-HT or LSD and intravenously with 5-HT, LSD, BOL or equimolar concentrations of 5-HT + LSD or 5-HT + BOL. Appropriate saline controls were included. They were then exposed to a standard amount of Noble-Collip trauma. Animals receiving 5-HT i.m. showed a significant multiphasic mortality curve after trauma depending on dose of drug. With small doses, mortality significantly exceeded controls, but fell to a value near controls as dose increased until a critical level was reached at which point mortality again rose considerably above controls. When rats received 5-HT, LSD or BOL intravenously in the doses used, no significant differences from control were seen following trauma. Thus, a difference in mortality from trauma is seen based on route of administration of 5-HT and LSD. When an equimolar combination of 5-HT + LSD was given i.v., a significant increase in mortality following trauma over rats receiving either 5-HT + BOL or saline was noted.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.