The muscle findings in the neuroleptic malignant syndrome associated with lysergic acid diethylamide.
W M Behan, A M Bakheit, P O Behan, I A More
Journal of Neurology, Neurosurgery, and Psychiatry August 1991 DOI: 10.1136/jnnp.54.8.741 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A patient who developed neuroleptic malignant syndrome after ingesting lysergic acid diethylamide (LSD) |
| Duration | One-year follow-up |
| Topics | LSD |
| Key findings | Muscle biopsy in a case of neuroleptic malignant syndrome following LSD ingestion showed focal necrosis, oedema, and hypercontracted fibres with glycogen and lipid depletion, all of which resolved completely one year later. The authors suggest these findings support the view that muscle rigidity in NMS is centrally mediated and drives the hyperpyrexia and its life-threatening complications, as they propose also occurs in malignant hyperthermia. |
Abstract
A detailed pathological description of the muscle findings in a case of the neuroleptic malignant syndrome (NMS) following ingestion of lysergic acid diethylamide (LSD) is given, including the first ultrastructural analysis. Focal necrosis, oedema, and hypercontraction of fibres with glycogen and lipid depletion, were identified, all of which had resolved completely a year later. The findings are compared with those in malignant hyperthermia. It is suggested that the results support the view that in NMS, the muscle rigidity is due to central mechanisms and, in both this disorder and malignant hyperthermia, it is responsible for the hyperpyrexia and its life-threatening complications.
Comparable studies
Other case reports and case series on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Patients with mental illness | 1957 | Case series | |
| Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases People who self-administered large amounts of pure LSD powder intranasally | 1975 | Case series | n = 8 |
| Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders Patients with chronic complex post-traumatic stress disorder (c-PTSD), dissociative,... | 2022 | Case series | |
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |