RNA synthesis in isolated brian nuclei after administration of d-lysergic acid diethylamide (LSD) in vivo.
Proceedings of the National Academy of Sciences March 1, 1975 DOI: 10.1073/pnas.72.3.837 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Young rabbits |
| Intervention | d-lysergic acid diethylamide (LSD) |
| Duration | 2.5 hr after administration |
| Topics | LSD |
| Keywords | Rna In vivo Transcription linguistics Molecular biology Biochemistry Pharmacology Genetics Receptor Plant-based medicinal research |
| Citations | 24 |
| Key findings | LSD stimulated RNA synthesis in isolated brain nuclei, with a 54% increase in brain stem and 13% in cerebral hemisphere nuclei over controls. |
Abstract
RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar RNA synthesis were increased. The main activity in the isolated nuclei assay was due to nucleoplasmic RNA polymerase, since alpha-amanitin reduced synthesis by over 70% in either drug or control treatments.