Lysergic Acid Diethylamide: Effect on Histone Acetylation in Rabbit Brain
Science June 13, 1975 DOI: 10.1126/science.1215990 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Dose | 10 and 100 micrograms per kilogram |
| Duration | 30 minutes after administration |
| Topics | LSD |
| Key findings | LSD increased histone acetylation in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration at doses of 10 and 100 micrograms per kilogram, with evidence of stimulated acetylation in individual histone bands after electrophoretic separation. |
Abstract
Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamide gels.