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Psychedelics use predicts more positive emotional reactivity and diminished outward-focused self-consciousness: the mediating role of ego dissolution and mystical experiences

Paweł Orłowski, Anastasia Ruban, Jan Szczypiński, Justyna Hobot, Maksymilian Bielecki, Michał Bola

September 23, 2021 preprint DOI: 10.31234/osf.io/k4xfg (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Cross-sectional survey
Sample size 2,516
Population Adults recruited via online survey, including 1,661 psychedelics users
Topics Ego dissolution Mystical experience
Key findings Lifetime psychedelic use was associated with greater positive and lower negative emotional reactivity, and with enhanced reflection and internal self-awareness but reduced rumination and public self-consciousness. Past ego-dissolution and mystical experiences mediated nearly all these relationships, suggesting they are central to long-term psychological effects.

Abstract

Background: Psychedelics are able to acutely alter emotional reactivity and self-consciousness. However, whether regular, naturalistic use of psychedelics can be linked to more persistent, trait-level changes in these domains remains an open question.Aim: To test three hypotheses: i) psychedelics use is related to higher positive and lower negative emotional reactivity; ii) psychedelics use is related to enhanced inward-focused self-consciousness and diminished outward-focused self-consciousness; iii) these relations are mediated by the intensity of past ego-dissolution and mystical experiences.Methods: Data from 2,516 participants (1,661 psychedelics users) were collected via an online survey. The survey included questions about the history of psychoactive substance use, questionnaires measuring trait-levels of emotional reactivity and self-consciousness, and questionnaires for retrospective assessment of ego-dissolution and mystical experiences. Data were analyzed using robust linear regression and mediation analysis.Results: First, a higher number of lifetime psychedelic experiences predicted greater positive and lower negative emotional reactivity. Second, in the domain of self, it predicted greater reflection and internal self-awareness, and reduced rumination tendency and public self-consciousness. Finally, intensity of past mystical and ego-dissolution experiences mediated almost all observed relationships between the lifetime psychedelics use and psychological variables.

Conclusions: Lifetime psychedelics use predicts an adaptive pattern of trait-level emotional reactivity and self-consciousness. The past ego-dissolution and mystical experiences are essential in understanding the long-lasting psychological effects of psychedelics use. Our findings might potentially explain previous observations of increased well-being in psychedelics users.