Cross-validation of the ego dissolution scale: implications for studying psychedelics.
Steven Jay Lynn, Charlie W. McDonald, Fiona G. Sleight, Richard E. Mattson
Frontiers in Neuroscience December 5, 2023 DOI: 10.3389/fnins.2023.1267611 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Cross-sectional validation study Peer reviewed |
|---|---|
| Sample size | 527 |
| Population | Adults recruited online |
| Topics | Ego dissolution |
| Keywords | Psychedelics Consciousness research Altered states |
| Citations | 8 |
| Key findings | The Ego Dissolution Scale has a two-factor structure (Ego-Loss and Unity) with adequate reliability and strong convergent validity with related psychological measures, but not with neuroticism or social desirability. |
Abstract
Introduction: Ego dissolution, variously called Ego-Loss, self-loss, and ego disintegration, is a hallmark of psychedelic drug use. We cross-validated the 10-item Ego Dissolution Scale, which we developed to assess ego dissolution in everyday life, and we included comparator variables that expanded our original assessment of construct validity.
Methods: = 527) completed the measures online.
Results: We replicated the original two factor structure (i.e., subfactors: Ego-Loss and Unity/connectedness with others, the world, universe), and we determined that the total score (Cronbach's α = 0.79) and subfactors (Ego-Loss = 78; Unity = 0.83) possessed adequate-to-good reliability and strong convergent validity (e.g., mindfulness, hallucination-predisposition, sleep variables, personality variables, positive/negative affect transliminality, dissociation/depersonalization), while neuroticism, social desirability did not correlate highly with ego dissolution. We identified distinct patterns of relations of measures associated with the Ego-Loss vs. Unity subfactors.
Discussion: We discuss the implications of the use of the EDS for studying everyday aspects of ego dissolution, the long-term effects of psychedelic use, and the value of using the scale in conjunction with measures of the acute effects of psychedelics.
Comparable studies
Other cross-sectional and survey studies on ego dissolution, most cited first.
Citations in the library
Cited by 7
- Exploring serotonergic psychedelics as a treatment for personality disorders. Neuropharmacology July 1, 2025
- Ontologically Challenging Psychedelic Experiences: Considerations for Managing Associated Distress. Current Topics in Behavioral Neurosciences 2026
- Exploring Motivations, Experiences, and Consequences of Psychedelic Use in Aotearoa New Zealand. Journal of Psychoactive Drugs March 5, 2025
- How to set up a psychedelic study: Unique considerations for research involving human participants. Neuroscience & Biobehavioral Reviews July 1, 2026
- Mindfulness and psychotic-like experiences in nonclinical populations: a systematic review and two meta-analyses. Psychological Medicine February 4, 2026
and 2 more in the library
Cites 60
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