A randomized controlled trial of Mindfulness-Based Cognitive Therapy (MBCT) versus treatment-as-usual (TAU) for chronic, treatment-resistant depression: study protocol
Mira B. Cladder-Micus, J. Vrijsen, E. Becker, Rogier Donders, Jan Spijker, Anne E. M. Speckens
BMC Psychiatry November 9, 2015 DOI: 10.1186/s12888-015-0647-y (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Patients with chronic, treatment-resistant depression who have received antidepressant medication and cognitive behavioral therapy or interpersonal therapy |
| Interventions | Mindfulness-Based Cognitive Therapy treatment-as-usual |
| Topics | Depression Meditation |
| Key findings | The trial will examine the effectiveness of MBCT in reducing depressive symptoms in chronic, treatment-resistant depression. |
Abstract
BackgroundMajor depression is a common psychiatric disorder, frequently taking a chronic course. Despite provision of evidence-based treatments, including antidepressant medication and psychological treatments like cognitive behavioral therapy or interpersonal therapy, a substantial amount of patients do not recover. Mindfulness-Based Cognitive Therapy (MBCT) has been found to be effective in reducing relapse in recurrent depression, as well as lowering symptom levels in acute depression. The effectiveness of MBCT for chronic, treatment-resistant depression has only be studied in a few pilot trials. A large randomized controlled trial is necessary to examine the effectiveness of MBCT in reducing depressive symptoms in chronic, treatment-resistant depression.Methods/DesignA randomized-controlled trial is conducted to compare MBCT with treatment-as-usual (TAU). Patients with chronic, treatment-resistant depression who have received antidepressant medication and cognitive behavioral therapy or interpersonal therapy are included. Assessments take place at baseline and post intervention/TAU-period. The primary outcome are depressive symptoms. Secondary outcomes are: remission rates, quality of life, rumination, mindfulness skills and self-compassion. Patients in the TAU condition are offered to participate in the MBCT after the post TAU-period assessment. From all completers of the MBCT (MBCT condition and patients participating after the TAU-period), follow-up assessments are taken at three and six months after the completion of the MBCT.DiscussionThis trial will result in valuable information about the effectiveness of MBCT in chronic, treatment-resistant depressed patients who previously received antidepressant medication and psychological treatment.Trial registrationtrialregister.nl NTR4843, registered 14th October 2014.
Comparable studies
Other randomized controlled trials on depression, most cited first.
Citations in the library
Cited by 6
- Mindfulness-based cognitive therapy for obsessive-compulsive disorder: Study protocol for a randomized controlled trial with functional magnetic resonance imaging and a 6-month follow-up Journal of Health Psychology July 5, 2018
- Mindfulness: a new tool for the person with diabetes and for the chronic health worker. Literature Review The Journal of AMD September 1, 2018
- An Analysis of Mindfulness-Based Cognitive Therapy as an Effective Adjuvant in Depression Treatment Communications in Humanities Research May 30, 2025
- Follow-up outcomes of Mindfulness-Based Cognitive Therapy (MBCT) for patients with chronic, treatment-resistant depression. Journal of Affective Disorders May 1, 2023
- Effect of Mindfulness-Based Cognitive Therapy on Symptoms of Depression: A Systematic Review STRADA Jurnal Ilmiah Kesehatan November 1, 2020
and 1 more in the library
Cites 10
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- Mindfulness‐Based Cognitive Therapy for Nonremitted Patients with Bipolar Disorder CNS Neuroscience & Therapeutics April 2, 2011
- Mindfulness-based interventions for people diagnosed with a current episode of an anxiety or depressive disorder: a meta-analysis of randomised controlled trials. PLoS One June 15, 2016
and 5 more in the library