Non-Canonical Microstate Becomes Salient in High Density EEG During Propofol-Induced Altered States of Consciousness
Wen Shi, Yamin Li, Zhian Liu, Jing Li, Qiang Wang, Xiangguo Yan, Gang Wang
International Journal of Neural Systems January 23, 2020 DOI: 10.1142/s0129065720500057 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Intervention | Propofol |
| Topics | Altered states of consciousness |
| Key findings | A non-canonical EEG microstate F with a posterior central maximum appears and becomes salient during propofol-induced transition of consciousness, with significantly increased coverage, occurrence, and power in moderate sedation. |
Abstract
Dynamically assessing the level of consciousness is still challenging during anesthesia. With the help of Electroencephalography (EEG), the human brain electric activity can be noninvasively measured at high temporal resolution. Several typical quasi-stable states are introduced to represent the oscillation of the global scalp electric field. These so-called microstates reflect spatiotemporal dynamics of coherent neural activities and capture the switch of brain states within the millisecond range. In this study, the microstates of high-density EEG were extracted and investigated during propofol-induced transition of consciousness. To analyze microstates on the frequency domain, a novel microstate-wise spectral analysis was proposed by the means of multivariate empirical mode decomposition and Hilbert-Huang transform. During the transition of consciousness, a map with a posterior central maximum denoted as microstate F appeared and became salient. The current results indicated that the coverage, occurrence, and power of microstate F significantly increased in moderate sedation. The results also demonstrated that the transition of brain state from rest to sedation was accompanied by significant increase in mean energy of all frequency bands in microstate F. Combined with studies on the possible cortical sources of microstates, the findings reveal that non-canonical microstate F is highly associated with propofol-induced altered states of consciousness. The results may also support the inference that this distinct topography can be derived from canonical microstate C (anterior-posterior orientation). Finally, this study further develops pertinent methodology and extends possible applications of the EEG microstate during propofol-induced anesthesia.
Comparable studies
Other observational and cohort studies on altered states of consciousness, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the DMT experience assessed with multivariate EEG. 6 female, 7 male human participants | 2019 | Observational cohort | n = 13 |
| Measures of entropy and complexity in altered states of consciousness Subjects during resting wakefulness, different sleep stages, and epileptic seizures | 2017 | Observational study | |
| Altered States of Consciousness and Short-Term Psychological After-Effects Induced by the First Time Ritual Use of Ayahuasca in an Urban Context in Brazil First-time ayahuasca users in Santo Daime and União do Vegetal rituals | 2005 | Observational cohort | n = 28 |
| Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning Healthy individuals during sleep, individuals under general anesthesia, and patients... | 2022 | Observational cohort | n = 71 |
| Subanaesthetic ketamine and altered states of consciousness in humans Human volunteers | 2018 | Observational study | n = 15 |
Citations in the library
Cited by 7
- EEG Microstates in Altered States of Consciousness Frontiers in Psychology April 27, 2022
- Electrophysiological (EEG) microstates during dream‐like bizarre experiences in a naturalistic scenario using immersive virtual reality European Journal of Neuroscience September 11, 2024
- Frequency-specific microstate correlates of ciprofol-induced alterations of consciousness. Frontiers in Neuroscience 2026
- Brain connectivity changes of propofol-induced altered states of consciousness using High-Density EEG Source Estimation. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference July 1, 2022
- Reconfiguration of Electroencephalography Microstate Networks after Breath-Focused, Digital Meditation Training. Brain Connectivity March 1, 2021
and 2 more in the library
Cites 11
- Decoupling of the brain's default mode network during deep sleep Proceedings of the National Academy of Sciences June 19, 2009
- Dynamic functional connectivity and brain metastability during altered states of consciousness Neuroimage October 3, 2017
- Capturing the spatiotemporal dynamics of self-generated, task-initiated thoughts with EEG and fMRI. Neuroimage July 1, 2019
- EEG microstates as a tool for studying the temporal dynamics of whole-brain neuronal networks: A review. Neuroimage October 15, 2018
- Activation and Connectivity within the Default Mode Network Contribute Independently to Future-Oriented Thought Scientific Reports February 12, 2016
and 6 more in the library