The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis.
Behavioural Brain Research 1996 DOI: 10.1016/0166-4328(95)00162-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | PCP-induced psychosis closely resembles acute schizophrenia and involves both dopamine and NMDA/PCP receptor mechanisms. |
Abstract
Phencyclidine (PCP) produces a psychotic reaction in humans which closely resembles an acute episode of schizophrenia and has therefore been given an increasing amount of attention as a model for schizophrenia. The present article reviews the behavioral and neurochemical effects of PCP in both humans and animals. Where possible, comparisons are made between the effects of PCP and amphetamine. The merits of the dopamine versus NMDA/PCP receptor mediated expression of PCP-induced psychosis are discussed, as well as the importance of selecting behavioral models which are best suited to model the expression of psychosis, rather than the motor effects of psychotomimetics.