The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis.
R E Steinpreis
Behavioural Brain Research 1996 DOI: 10.1016/0166-4328(95)00162-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | PCP-induced psychosis closely resembles acute schizophrenia and involves both dopamine and NMDA/PCP receptor mechanisms. |
Abstract
Phencyclidine (PCP) produces a psychotic reaction in humans which closely resembles an acute episode of schizophrenia and has therefore been given an increasing amount of attention as a model for schizophrenia. The present article reviews the behavioral and neurochemical effects of PCP in both humans and animals. Where possible, comparisons are made between the effects of PCP and amphetamine. The merits of the dopamine versus NMDA/PCP receptor mediated expression of PCP-induced psychosis are discussed, as well as the importance of selecting behavioral models which are best suited to model the expression of psychosis, rather than the motor effects of psychotomimetics.
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- Phencyclidine-Based New Psychoactive Substances. Handbook of experimental pharmacology 2018
- Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT(1A) Receptor-Dependent Mechanism. Neuropsychopharmacology February 2012
- Ultrasonic vocalisations explain unexpected effects on pre-pulse inhibition responses in rats chronically pre-treated with phencyclidine. Behavioural Brain Research September 14, 2009
- Baseline temperature in an animal model of schizophrenia: long-term effects of perinatal phencyclidine administration. Physiology & Behavior February 27, 2008
and 13 more in the library
Cites 13
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate British Journal of Pharmacology June 1, 1983
- Cerebellar toxicity of phencyclidine Journal of Neuroscience March 1, 1995
- Clinical pharmacology of phencyclidine toxicity American Journal of Psychiatry November 1, 1977
- N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis. Journal of Pharmacology and Experimental Therapeutics June 1, 1990
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