Phencyclidine intoxication: insights into a growing problem of drug abuse.
Postgraduate medicine November 1980 DOI: 10.1080/00325481.1980.11715603 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
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| Key points | The text states that PCP abuse is a growing problem and that PCP intoxication produces diverse, somewhat dose-dependent physical and psychiatric effects. It notes that PCP's effects have historically been considered remarkably similar to schizophrenia, yet neuropharmacologic data are somewhat inconsistent with the dopamine hypothesis of schizophrenia, and that urine acidification may hasten drug excretion. |
Abstract
Phencyclidine (PCP) is a dissociative anesthetic whose abuse is a growing problem. Historically, its effects have been considered remarkably like those of the schizophrenic state, but in vitro and in vivo neuropharmacologic data are somewhat inconsistent with the dopaminergic hypothesis of schizophrenia. The physiologic and psychiatric manifestations of PCP intoxication are diverse and somewhat dose dependent. Urine acidification may hasten drug excretion.