Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations.
Oliver Howes, Paul Shotbolt, Michael Bloomfield, Kirstin Daalman, Arsime Demjaha, Kelly Diederen, Kemal Ibrahim, Euitae Kim, Philip Mcguire, René S. Kahn, Iris E C Sommer
Schizophr Bull January 26, 2012 DOI: 10.1093/schbul/sbr195 (opens in new tab) via PubMed Central
Summary
AI-generated from the abstractAuditory hallucinations in healthy individuals are associated with altered dopamine function in the brain. Using [18F]-DOPA PET imaging, the study found that healthy people who experience auditory hallucinations show differences in dopaminergic activity compared to those who do not, suggesting that dopamine dysfunction may be a trait marker along the psychosis spectrum. The findings indicate that even in the absence of a clinical diagnosis, hallucination proneness is linked to measurable neurochemical variations.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Healthy individuals with auditory hallucinations |
| Citations | 94 |
| Key finding | Auditory hallucinations in healthy individuals are associated with altered dopaminergic function in the brain. |
Abstract
Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations.