European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
June 1, 2019
Matthijs G. Bossong, Hendrika H Van Hell, Chris D Schubart et al.
Cannabis produces a broad range of acute, dose-dependent psychotropic effects. Only a limited number of neuroimaging studies have mapped these effects by examining the impact of cannabis on resting state brain neurophysiology. Moreover, how genetic variation influences the acute effects of cannabis on resting state brain function is unknown. Here we investigated the acute effects of...
Psychopharmacology
February 2012
Hendrika H Van Hell, Gerry Jager, Matthijs G. Bossong et al.
Disturbed reward processing in humans has been associated with a number of disorders, such as depression, addiction, and attention-deficit hyperactivity disorder. The endocannabinoid (eCB) system has been implicated in reward processing in animals, but in humans, the relation between eCB functioning and reward is less clear. The current study uses functional magnetic resonance imaging (fMRI) to...
Schizophr Bull
January 26, 2012
Oliver Howes, Paul Shotbolt, Michael Bloomfield et al.
94 citations
Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations.
The International Journal of Neuropsychopharmacology
April 14, 2011
Hendrika H Van Hell, Matthijs G. Bossong, Gerry Jager et al.
61 citations
The main reason for recreational use of cannabis is the 'high', the primary psychotropic effect of Δ9-tetrahydrocannabinol (THC). This psychoactive compound of cannabis induces a range of subjective, physical and mental reactions. The effect on heart rate is pronounced and complicates bloodflow-based neuroimaging of psychotropic effects of THC. In this study we investigated the effects of THC...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
February 2009
Matthijs G Bossong, Bart N M Van Berckel, Ronald Boellaard et al.
The influence of cannabis on mental health receives growing scientific and political attention. An increasing demand for treatment of cannabis dependence has refueled the discussion about the addictive potential of cannabis. A key feature of all addictive drugs is the ability to increase synaptic dopamine levels in the striatum, a mechanism involved in their rewarding and motivating effects....
Psychopharmacology
August 2007
Gerry Jager, Maartje M De Win, Hylke K Vervaeke et al.
Heavy ecstasy use in humans has been associated with cognitive impairments and changes in cognitive brain function supposedly due to damage to the serotonin system. There is concern that even a single dose of 3,4-methylenedioxymethamphetamine may be neurotoxic, but very little is known about the consequences of a low dose of ecstasy for cognitive brain function. The objective of the study was...