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Effect of N,N-Dimethyltryptamine and D-Lysergic Acid Diethylamide on the Release of 5-Hydroxyindoles in Rat Forebrain

Mirjana Randić, Ante L. Padjen

Nature April 1, 1971 DOI: 10.1038/230532a0 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental study Peer reviewed
Population Thin titanium films
Dose 350 eV deuterium ions at 0.2-0.4 mA/cm2
Measures Silicon charged particle detector
Topics LSD Serotonin 5-MeO-DMT DMT
Keywords Forebrain Stimulation Pharmacology Endocrinology Biochemistry Central nervous system Receptor
Citations 27
Key findings Deuterium ion bombardment of titanium films at ambient temperature produces 5 MeV hydrogen isotopes at a rate of 10^-16 events per deuteron pair per second.

Abstract

Thin titanium films have been bombarded with low energy (350 eV) deuterium ions at high current density (0.2-0.4 mA.cm2) to investigate the reported occurrence of nuclear reactions at ambient temperatures in deuterium charged metals. A silicon charged particle detector was used to search for charged particles produced by such reactions. Evidence is reported for the detection of hydrogen isotopes with 5 MeV energy at a rate of 10-16 events/deuteron pair/s. Low energy deuterium (350 eV) ions produced by an ECR microwave source impinge normally on a thin metal film in vacuum, while a Si particle detector placed directly behind the film detects particle emission. The advantages of this method are rapid and efficient deuterium charging of any material (including insulators), high particle detection efficiency and sensitivity (low background), and the ability to measure the particle energy and determine the particle type. Titanium was chosen as the target because previous work by Jones had shown neutron emission and because Ti retains more hydrogen near room temperature than does PD.

Comparable studies

Other experimental studies on 5-MeO-DMT, most cited first.

Study Year Design Participants
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Human cerebral organoids 2017 Experimental study
Bufo alvarius: a potent hallucinogen of animal origin. Bufo alvarius toad venom 1994 Experimental study
Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment Volunteers 2019 Within-subjects experimental study n = 11
Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Adult cats 1990 Experimental study n = 10
Studies on the Mechanism of Action of Monoamine Oxidase: Metabolism of N,N-Dimethyltryptamine and N,N-Dimethyltryptamine-N-Oxide 1962 Experimental study

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LSD Serotonin 5-MeO-DMT DMT