Actions of Mescaline on Isolated Rat Atria
Peter K. S. Siegl, Raymond F. Orzechowski
Journal of Pharmaceutical Sciences July 1, 1977 DOI: 10.1002/jps.2600660708 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Isolated rat atria |
| Intervention | Mescaline |
| Dose | 5 x 10(-4) and 1 x 10(-3) M |
| Topics | Mescaline |
| Keywords | Chronotropic Inotrope Metiamide Contraction grammar Atrium architecture Histaminergic Contractility Pharmacology Heart rate Endocrinology Blood pressure Antagonist Histamine h2 receptor |
| Citations | 2 |
| Key findings | Mescaline's positive inotropic effect in rat atria is secondary to its negative chronotropic effect and is not mediated by histamine receptors. |
Abstract
Mescaline, in concentrations of 5 x 10(-4) and 1 x 10(-3) M, produced negative chronotropic and positive inotropic responses in isolated, spontaneously beating rat atria. In tissues driven at a constant rate, the inotropic response was diminished greatly, indicating that the increment in the force of contraction was secondary to the reduction in rate. These chronotropic and inotropic responses were not altered consistently by pretreatment with the histamine antagonists chlorpheniramine and metiamide.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |
Citations in the library
Cited by 2
- Cardiac effects of ephedrine, norephedrine, mescaline, and 3,4-methylenedioxymethamphetamine (MDMA) in mouse and human atrial preparations Naunyn-Schmiedeberg's Archives of Pharmacology November 1, 2022
- Effects of congeners of amphetamine on the human heart Naunyn-Schmiedeberg's Archives of Pharmacology February 10, 2024