Effects of congeners of amphetamine on the human heart
Joachim Neumann, Stefan Dhein, Uwe Kirchhefer, Britt Hofmann, Ulrich Gergs
Naunyn-Schmiedeberg s Archives of Pharmacology February 10, 2024 DOI: 10.1007/s00210-024-02983-2 (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractThis review examines how amphetamine and its congeners, both stimulant and hallucinogenic, can directly and indirectly harm the heart. Focusing on isolated human heart muscle preparations, the authors assess whether these drugs alter cardiac contractility and describe the underlying mechanisms. They conclude that such drugs can have cardiac side effects leading to morbidity and death. Based on the current knowledge, the authors propose specific areas for further research to better understand these effects.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Keywords | Contractility Human heart Hallucinogen Pharmacology Affect linguistics |
| Citations | 2 |
| Key finding | Argues that amphetamine and its congeners can have direct and indirect harmful effects on the mammalian heart, including altering cardiac contractility, and that these effects can lead to morbidity and death. |
Abstract
Central stimulatory and hallucinogenic drugs of abuse like amphetamine and most congeners of amphetamine can have cardiac harmful effects. These cardiac side effects can lead to morbidities and death. In this paper, we review current knowledge on the direct and indirect effects of these amphetamine congeners on the mammalian heart-more specifically, the isolated human heart muscle preparation. In detail, we address the question of whether and how these drugs affect cardiac contractility and their mechanisms of action. Based on this information, further research areas are defined, and further research efforts are proposed.