Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions.
Experimental Biology and Medicine 1956 DOI: 10.3181/00379727-91-22163 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Uterus of spayed rat |
| Interventions | Frenquel chlorpromazine reserpine mescaline LSD atropine |
| Topics | LSD Mescaline Serotonin |
| Keywords | Chlorpromazine Reserpine Uterus Oxytocin Atropine Pharmacology Endocrinology Serotonin antagonists Hallucinogen Antagonism Uterine contraction |
| Citations | 64 |
| Key findings | Tranquilizing drugs antagonize serotonin-induced uterine contractions, while mescaline facilitates serotonin activity, and LSD shows dose-dependent dual effects—antagonism at high concentrations and facilitation at low concentrations. |
Abstract
SummaryTranquilizing drugs: Frenquel (0.8 mg/1), chlorpromazine (0.1 mg/1) and reserpine (0.4 mg/1), antagonize serotonin-induced uterine contractions, though they do not affect sensitivity of the uterus of the spayed rat either to ACh or oxytocin. The period of antagonism is longer lasting with reserpine than with chlorpromazine and is shortest with Frenquel. Mescaline (0.1 mg/1) causes a facilitation of serotonin activity, and in highest amounts causes a uterine contraction by itself. However, it is not antagonized by atropine (0.24 mg/1). A relatively high concentration of LSD (1 γ/1) antagonizes both serotonin and mescaline-induced uterine activity. In contrast low concentrations of LSD (0.05 to 0.2 γ/1) facilitate the effects of serotonin and of mescaline on the rat uterus.
Comparable studies
Other experimental studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin | 2000 | Experimental study | |
| Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Rat brain | 1988 | Experimental study | |
| The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Human platelet plasma membrane vesicles and bovine adrenal chromaffin granule membrane... | 1992 | Laboratory study | |
| 5-HT2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex Rat brain | 1997 | Experimental study |
Citations in the library
Cited by 7
- Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Science August 16, 1968
- Adverse consequences of lysergic acid diethylamide Addiction October 1, 1993
- Serotonin-Sensitive Adenylate Cyclase in Neural Tissue and Its Similarity to the Serotonin Receptor: A Possible Site of Action of Lysergic Acid Diethylamide Proceedings of the National Academy of Sciences March 1, 1974
- Lysergic acid diethylamide: Role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine) Science 1969
- Studies on the Diethylamide of Lysergic Acid (LSD-25) A M A Archives of Neurology & Psychiatry April 1, 1957
and 2 more in the library