Psychotomimetics potentiate locomotor hyperactivity induced by dopaminergic drugs.
Heidrun Fink, R Morgenstern, Wolfgang Oelssner
Pharmacology, Biochemistry, and Behavior November 1979 DOI: 10.1016/0091-3057(79)90028-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Apomorphine d LSD mescaline DMT cyproheptadine |
| Measures | open-field test |
| Key findings | Low doses of LSD, mescaline, and DMT alone did not alter locomotor activity but strongly potentiated apomorphine- and d,l-amphetamine-induced hypermotility in rats. Cyproheptadine blocked LSD's potentiating effect without affecting apomorphine-induced hypermotility, which the authors interpret as indicating causal serotonergic involvement in the potentiation. |
Abstract
The spontaneous locomotor activity of rats was investigated in an open-field test. Apomorphine and d,1-amphetamine caused a dose dependent increase of locomotor activity. LSD, mescaline, and DMT in low doses were ineffective, when given alone, but caused a strong potentiation of the hypermotility induced by apomorphine and d,1-amphetamine. Cyproheptadine antagonized the potentiating effect of LSD without affecting the hypermotility induced by apomorphine, indicating a causal serotonergic involvement in the potentiation effect.