Neuromyal blocking action of mescaline
Robert T. Schopp, William F. Kreutter, Steven V. Guzak
American Journal of Physiology-Legacy Content June 1, 1961 DOI: 10.1152/ajplegacy.1961.200.6.1226 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Dog neuromuscular preparation |
| Intervention | Mescaline |
| Dose | adequate doses |
| Topics | Mescaline |
| Keywords | Curare Paralysis Stimulation Denervation Pharmacology Anesthesia |
| Citations | 13 |
| Key findings | Mescaline causes paralysis by acting on the neuromuscular complex, and its effects can be opposed by adrenaline, KCl, and prostigmine. |
Abstract
The close intra-arterial injection of mescaline in adequate doses causes partial or complete paralysis in the dog neuromuscular preparation. Mescaline and curare tend to supplement one another with respect to their depressant actions on indirectly stimulated skeletal muscle. After complete blockade with mescaline, the muscle can readily be activated by direct stimulation. Following chronic denervation, the directly stimulated muscle fails to show an immediate depression of contractions when mescaline is administered. Adrenaline, KCl and prostigmine can oppose the paralyzing action of mescaline. The site of action of mescaline in producing paralysis is localized in the neuromuscular complex.
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Rabbit lung | 1961 | Experimental study | |
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study |