Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens
Journal of Psychoactive Drugs October 1, 1986 DOI: 10.1080/02791072.1986.10472362 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Hallucinogen Identification biology Mechanism biology Class philosophy Psychotherapist Pharmacology Epistemology Artificial intelligence |
| Citations | 568 |
| Key points | Proposes that MDMA and MBDB are 'entactogens,' a new therapeutic class distinct from classic hallucinogens and stimulants, based on differences in mechanism of action and subjective effects. |
Abstract
(1986). Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 305-313.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
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State of the evidence: MDMA Unclear
Argues that MDMA and MBDB form a distinct therapeutic class, 'entactogens,' separate from classic hallucinogens and stimulants.
Synthesized
Comparable studies
Other theoretical and historical papers on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The Background and Chemistry of MDMA | 1986 | Historical analysis | |
| The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents* Original documents in Merck's historical archive in Darmstadt, Germany, years 1900–1960 | 2006 | Historical analysis | |
| Distinct neural mechanisms for the prosocial and rewarding properties of MDMA | 2019 | Theoretical or philosophical paper | |
| How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale | 2009 | Theoretical or philosophical paper | |
| The 21st century psychedelic renaissance: heroic steps forward on the back of an elephant | 2017 | Theoretical or philosophical paper |
Citations in the library
Cited by 260
- Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Journal of Neuroscience August 1, 1988
- Recreational MDMA use in Sydney: a profile of ‘Ecstasy’ users and their experiences with the drug British Journal of Addiction August 1, 1992
- MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology September 1, 2019
- Gender differences in the subjective effects of MDMA Psychopharmacology March 5, 2001
- Psychedelics and the Human Receptorome PLoS One 2010
and 255 more in the library
Cites 9
- Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class Journal of Medicinal Chemistry October 1, 1986
- Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes Journal of Medicinal Chemistry May 1, 1982
- 3,4-Methylenedioxymethamphetamine (MDMA): stereoselective interactions at brain 5-HT1 and 5-HT2 receptors. Psychopharmacology 1986
- Further investigation of the discriminative stimulus properties of MDA. Pharmacology, Biochemistry, and Behavior April 1984
- MDA: a psychoactive agent with dual stimulus effects. Life Sciences January 23, 1984
and 4 more in the library