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Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens

David E. Nichols

Journal of Psychoactive Drugs October 1, 1986 DOI: 10.1080/02791072.1986.10472362 (opens in new tab) via OpenAlex

Summary

AI-generated from the abstract

MDMA, MBDB, and classic hallucinogens have distinct mechanisms of action. MDMA and MBDB produce a unique psychological profile characterized by enhanced empathy and emotional openness, differing from both stimulants and hallucinogens. This profile defines a new therapeutic class called entactogens. The paper argues that entactogens, by their specific neurochemical effects, offer potential for psychotherapy distinct from that of classic hallucinogens or amphetamines.

Study at a glance

Characteristics Theoretical or philosophical paper Peer reviewed
Topics MDMA
Keywords Hallucinogen Psychology Identification biology Mechanism biology
Citations 568
Key finding Proposes that MDMA and MBDB are 'entactogens,' a new therapeutic class distinct from classic hallucinogens and stimulants, based on differences in mechanism of action and subjective effects.

Abstract

(1986). Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 305-313.

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