Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Boris D. Heifets, Juliana S Salgado, Madison Taylor, Paul Hoerbelt, Daniel F. Cardozo Pinto, Elizabeth E. Steinberg, Jessica J. Walsh, Ji Ying Sze, Robert C. Malenka
Science Translational Medicine December 11, 2019 DOI: 10.1126/scitranslmed.aaw6435 (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractMDMA's prosocial effects can be separated from its addictive properties by using fenfluramine, a selective serotonin-releasing compound. This finding reveals a conserved neuronal pathway that could be targeted to develop new therapeutics with limited abuse liability, offering a potential strategy for creating safer treatments that promote social connection without the risks of addiction.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Prosocial behavior Neuroscience Psychology Pharmacology |
| Citations | 119 |
| Key finding | Argues that fenfluramine can produce prosocial effects similar to MDMA without addictive properties, identifying a conserved neuronal pathway for developing safer therapeutics. |
Abstract
-fenfluramine, a selective serotonin-releasing compound. By dissociating the mechanisms of MDMA's prosocial effects from its addictive properties, we provide evidence for a conserved neuronal pathway, which can be leveraged to develop novel therapeutics with limited abuse liability.