Structure-Activity Relationships of MDMA and Related Compounds: A New Class of Psychoactive Agents?
David F. Nichols, Robert Oberlender
Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA 1990 DOI: 10.1007/978-1-4613-1485-1_7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Drug discrimination Training dose Complete substitution Discriminative stimulus property |
| Citations | 6 |
| Key findings | MDMA and related substances appear to constitute a novel pharmacological class called entactogens, with discriminative stimulus properties distinct from other drug classes. |
Abstract
It has been hypothesized that MDMA and substances that possess a psychopharmacological effect similar to MDMA are members of a novel pharmacological class named entactogens [1–3]. In this chapter evidence will be presented to support this, through a discussion of the data acquired in efforts directed toward testing this hypothesis. Although these studies are far from complete, the results gathered thus far, together with those from other laboratories, support the view that the pharmacology of entactogens is clearly different from other known classes of compounds.
Comparable studies
Other narrative reviews on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Human Pharmacology of MDMA | 2004 | Review | |
| Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research | 2001 | Review | |
| 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans | 1994 | Review | |
| (±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Studies in Animals | 2000 | Review | |
| Amphetamine toxicities | 2010 | Review |
Citations in the library
Cited by 6
- The Neuropsychopharmacology and Toxicology of 3,4‐methylenedioxy‐N‐ethyl‐amphetamine (MDEA) CNS Drug Reviews June 1, 2004
- La psychothérapie assistée par la MDMA dans la prise en charge du syndrome de stress post-traumatique Psychologie Francaise June 29, 2021
- Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat. Progress in Neuro-Psychopharmacology and Biological Psychiatry April 2001
- 3,4-Methylenedioxy analogues of amphetamine: defining the risks to humans. Neuroscience and biobehavioral reviews March 1999
- Neuroendocrine and cardiovascular effects of MDE in healthy volunteers. Neuropsychopharmacology May 1993
and 1 more in the library
Cites 6
- Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens Journal of Psychoactive Drugs October 1, 1986
- Subjective Reports of the Effects of MDMA in a Clinical Setting Journal of Psychoactive Drugs October 1, 1986
- Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class Journal of Medicinal Chemistry October 1, 1986
- Behavioral properties of psychoactive phenylisopropylamines in rats. European Journal of Pharmacology December 17, 1981
- MDA: a psychoactive agent with dual stimulus effects. Life Sciences January 23, 1984
and 1 more in the library