Lysergic acid diethylamide: evidence for stimulation of cerebral dopamine receptors
M. Da Prada, A. Saner, W.p. Burkard, G. Bartholini, A. Pletscher
Brain Research August 1, 1975 DOI: 10.1016/0006-8993(75)90877-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats and cats |
| Intervention | Lysergic acid diethylamide (LSD) |
| Topics | LSD |
| Keywords | Homovanillic acid Caudate nucleus Stimulation Dopamine receptor Endocrinology Adenylate kinase Central nervous system |
| Citations | 71 |
| Key findings | LSD stimulates dopamine receptors in the central nervous system, which may be involved in LSD-induced psychosis. |
Abstract
In the rat, lysergic acid diethylamide (LSD) decreased the striatal and retinal content of homovanillic acid. LSD did not change the level of dopamine (DA), but delayed the a-methyl-p-tyrosine-induced disappearance of this amine in the teldiencephalon. In the cat, LSD diminished the DA output into the perfusate of the caudate nucleus. Furthermore, LSD increased the activity of adenylate cyclase in striatal homogenates of rat. These and other findings indicate that in the central nervous system LSD stimulates DA receptors which may be involved in LSD-induced phychosis.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 11
- Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro Life Sciences June 1, 1998
- Comparison of the action of lysergic acid diethylamide and apomorphine on the copulatory response in the female rat Psychopharmacology 1976
- Distortions of Vision and Pain: Two Functional Facets of D-Lysergic Acid Diethylamide Perceptual and Motor Skills December 1, 1979
- Hallucinogens. Pharmacology & Therapeutics February 1, 2004
- Lysergic acid diethylamide: Evidence for stimulation of pituitary dopamine receptors Psychopharmacology 1977
and 6 more in the library
Cites 3
- Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide British Journal of Pharmacology September 1, 1968
- Lysergic acid diethylamide: Role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine) Science 1969
- Studies on the Diethylamide of Lysergic Acid (LSD-25) A M A Archives of Neurology & Psychiatry April 1, 1957