Lysergic acid diethylamide: Evidence for stimulation of pituitary dopamine receptors
Herbert Y. Meltzer, Richard G. Fessler, Miljana Simonovic, John Doherty, Victor S. Fang
Psychopharmacology 1977 DOI: 10.1007/bf00426539 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male rats |
| Interventions | LSD methysergide apomorphine chlorpromazine alpha-methylparatyrosine quipazine |
| Dose | 0.05 mg/kg and 0.20 mg/kg |
| Topics | LSD Serotonin |
| Keywords | Prolactin Dopamine Methysergide Chlorpromazine Quipazine Alpha-methylparatyrosine Apomorphine |
| Key findings | LSD has potent dopamine agonist properties that directly or indirectly inhibit prolactin secretion in male rats. |
Abstract
Lysergic acid diethylamide (LSD), 0.05 mg/kg and 0.20 mg/kg, significantly decreased plasma prolactin (PRL) levels in male rats. LSD, 0.20 mg/kg, also inhibits the increase in plasma PRL levels produced by chlorpromazine (CPZ), 5 mg/kg, and alpha-methylparatyrosine (AMPT), 50 mg/kg, both of which interfere with dopaminergic inhibition of PRL secretion. LSD was more potent than methysergide, a serotonin receptor blocker, in lowering plasma PRL levels and more potent than apomorphine, a known direct acting dopamine agonist, in blocking the increase in plasma PRL produced by quipazine, a 5-HT agonist. These results suggest LSD has potent dopamine agonist properties on the rat pituitary or hypothalamic dopamine receptors which directly or indirectly inhibit PRL secretion.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 14
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Biological Psychiatry November 29, 2014
- d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology International Journal of Molecular Sciences November 23, 2016
- Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro Life Sciences June 1, 1998
- Interaction between LSD and dopamine D2/3 binding sites in pig brain Synapse 2005
and 9 more in the library
Cites 5
- Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide British Journal of Pharmacology September 1, 1968
- Lysergic acid diethylamide: evidence for stimulation of cerebral dopamine receptors Brain Research August 1, 1975
- Interactions between lysergic acid diethylamide and dopamine-sensitive adenylate cyclase systems in rat brain Brain Research August 1, 1975
- Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli Psychopharmacology 1971
- LSD-Induced Decrease in Serum Prolactin in Rats Experimental Biology and Medicine September 1, 1971