Distortions of Vision and Pain: Two Functional Facets of D-Lysergic Acid Diethylamide
Perceptual and Motor Skills December 1, 1979 DOI: 10.2466/pms.1979.49.2.499 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Intervention | LSD |
| Topics | LSD |
| Citations | 2 |
| Key points | Proposes that LSD's visual effects arise from attenuation of light-evoked input to the dorsal lateral geniculate nucleus and its analgesic effects from actions on a centrifugally controlled pain system involving midbrain raphe neurons. |
Abstract
D-lysergic acid diethylamide (LSD) produces distortions of visual perception and analgesia. Evidence is advanced from a functional standpoint that the observed visual effects result from an attenuation of light-evoked input to the dorsal lateral geniculate nucleus (LGN) from the purely centripetal pathways of the retina. More slowly responding visual afferents or those with more complex receptive fields seem to be affected most. LSD analgesia, accompanied by severe psychotic symptoms, appears to result from drug actions on a centrifugally controlled pain system involving neurons of the midbrain raphe.