Differential Behavioral Responsivity to LSD-25
Archives of General Psychiatry June 1, 1963 DOI: 10.1001/archpsyc.1963.01720120031005 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Chronic schizophrenics and normal adults |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | Schizophrenia object-oriented programming Relevance law Action physics Mechanism biology Clinical psychology Cognitive psychology Epistemology |
| Citations | 15 |
| Key findings | Chronic schizophrenics show less psychological response to a given dose of LSD-25 than do normal adults. |
Abstract
The major question posed in this report is whether chronic schizophrenics show less psychologic response to the administration of a given dosage of lysergic acid diethylamide (LSD-25) than do normal adults. Data relevant to this question are of importance in at least three ways: (1) they are of relevance in delineating the mechanism of action of LSD insofar as such mechanisms—whether psychological, physiological, biochemical, etc—must be broadly enough conceived to encompass differences in effect of LSD in schizophrenics and normals; (2) they provide a fuller picture of similarities and differences between schizophrenics and normals and thereby contribute to a theoretical understanding of schizophrenia; and (3) they contribute to the body of evidence pertinent to the question whether "biochemical sluggishness" is a general characteristic of schizophrenia. The literature concerning the relative responsivity of normals and schizophrenics to LSD-25 is controversial. The several historical
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 8
- Phenomenology, Structure, and Dynamic of Psychedelic States Current Topics in Behavioral Neurosciences 2016
- Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers Neuropsychopharmacology September 28, 2011
- Acute LSD effects on response inhibition neural networks Psychological Medicine October 2, 2017
- LSD, madness and healing: Mystical experiences as possible link between psychosis model and therapy model. Psychological Medicine March 1, 2023
- Psychedelics and creativity: a review of the quantitative literature
and 3 more in the library
Cites 9
- The Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1954
- LYSERGIC ACID DIETHYLAMIDE (LSD-25) American Journal of Psychiatry June 1, 1952
- EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25) American Journal of Psychiatry February 1, 1952
- CLINICAL REACTIONS AND TOLERANCE TO LSD IN CHRONIC SCHIZOPHRENIA The Journal of Nervous and Mental Disease September 1, 1955
- Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1957
and 4 more in the library