DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO
Journal of Neurochemistry July 1, 1976 DOI: 10.1111/j.1471-4159.1976.tb01546.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Young rabbits |
| Dose | 10 or 100 μg/kg body wt |
| Duration | Up to 4 hours |
| Topics | LSD |
| Keywords | Polysome In vivo Dose Pharmacology Endocrinology Biochemistry |
| Citations | 42 |
| Key findings | In vivo administration of LSD transiently disaggregates polysomes and reduces protein synthesis in the brains of young rabbits. |
Abstract
Abstract— Polysomes from three major brain regions of the young rabbit were disaggregated after in vivo administration of d ‐LSD. The effect was transient and demonstrated maximal shift after 30–60 min with a return to normal levels by 4 h. Brain polysome disaggregation was elicited by LSD dosages of either 10 or 100/μg/kg body wt. The polysome shift was not caused by RNase degradation and during maximal disaggregation there was a measurable decrease in protein synthesis.
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| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |