Comparison of the Chromosomal Patterns Obtained from Groups of Continued Users, Former Users, and Nonusers of LSD-25
Lewis L. Judd, W.w. Brandkamp, William H. Mcglothlin
American Journal of Psychiatry November 1, 1969 DOI: 10.1176/ajp.126.5.626 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Single-blind study Longitudinal Peer reviewed |
|---|---|
| Sample size | 25 |
| Population | Heavy users of LSD-25 (current and former) and drug-free control subjects |
| Topics | LSD |
| Keywords | Chromosome Ingestion Population Physiology Genetics |
| Citations | 16 |
| Key points | No significant differences in chromosome breakage rates were found between heavy LSD users and drug-free controls, with mean breakage rates of 1.8% or less across all groups. |
Abstract
In a single-blind study chromosome analyses were performed on three groups of subjects: 1) nine heavy users of LSD-25 who have continued to use the drug; 2) eight heavy users of LSD-25 who have ceased to use it; and 3) eight drug-free control subjects. The results revealed no significant differences in chromosome break-age rates between any of the three groups and therefore no temporal factor was elicited regarding chromosome damage and LSD ingestion. The mean breakage rates for all three groups were 1.8 percent or less and did not support earlier findings that LSD ingestion causes an increase in chromosome aberrations over those observed in a normal control population. The authors emphasize the need for a more controlled longitudinal study.