Combined mindfulness-based stress reduction and physical activity improved psychological factors and sleep quality in patients with MDD: A randomized controlled trial study.

Ebrahim Norouzi; Azadeh Naseri; Leeba Rezaie; Amy M Bender; Nader Salari; Habibolah Khazaie

doi:10.1016/j.apnu.2024.10.020

Combined mindfulness-based stress reduction and physical activity improved psychological factors and sleep quality in patients with MDD: A randomized controlled trial study.

Ebrahim Norouzi, Azadeh Naseri, Leeba Rezaie, Amy M Bender, Nader Salari, Habibolah Khazaie

Archives of Psychiatric Nursing December 1, 2024 DOI: 10.1016/j.apnu.2024.10.020 (opens in new tab)

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Study at a glance

AI-extracted from the abstract

Characteristics	Randomized controlled trial Peer reviewed
Sample size	67
Population	Outpatients with major depressive disorder (MDD) for at least 2 months, currently on sertraline treatment
Interventions	Physical activity MBSR Combination MBSR and physical activity
Duration	8-week intervention, 4-week follow-up
Topics	Depression Meditation
Keywords	Physical activity Sertraline Sleep disorders
Citations	12
Key findings	Combining MBSR and physical activity with sertraline treatment reduced sleep disturbances, depression, anxiety, and perceived stress more than sertraline alone or either intervention alone.

Abstract

Non-pharmacological interventions are available to improve sleep quality including mindfulness-based stress reduction (MBSR) and physical activity (PA). The present study aimed to evaluate the effectiveness of the combination of MBSR and PA interventions as an augmentation to treatment as usual with sertraline to improve sleep and psychological factors among patients with MDD. Sixty-seven patients in outpatient care diagnosed with MDD for a minimum of 2 months (mean age: 35.32 ± 7.8; 65 % female) and currently on sertraline treatments were randomized into four groups including: 1) Physical activity, 2) MBSR, 3) Combination MBSR and physical activity (MBSRPA), and 4) Control. All participants completed self-reported questionnaires on sleep quality, depression, anxiety, and perceived stress from baseline to 8 weeks later at post-test and four weeks later at follow-up. Over time, sleep disturbance and psychological problems were reduced in all conditions when compared to the control. Moreover, MBSRPA had a more positive impacts on perceived stress, anxiety, depressive symptoms and sleep quality. The results of the present study confirmed the effectiveness of MBSRPA as an augmentation to standard therapy to help reduce symptoms of depression, anxiety, perceived stress, and sleep problems in patients with MDD.

Comparable studies

Other randomized controlled trials on depression, most cited first.

Study	Year	Design	Participants
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Subjects with DSM-IV major depression (treatment resistant)	2006	Randomized, placebo-controlled, double-blind crossover study	n = 18
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients	2000	Randomized controlled trial	n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety	2016	Randomized controlled trial	n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression	2016	Double-blind, placebo-controlled, crossover trial	n = 29
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients	2004	Randomized controlled trial	n = 73

Citations in the library

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