Effects of acute administration of 5-methoxy-N,N-dimethyltryptamine upon the latency and duration of post-decapitation convulsions.
Acta Pharmacologica et Toxicologica September 1, 1984 DOI: 10.1111/j.1600-0773.1984.tb02041.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-methoxy-N N-dimethyltryptamine methergoline p-chloroamphetamine p-chlorophenylalanine |
| Dose | 0.5 mg/kg, 2.0 mg/kg, 2x10 mg/kg, 1 x 300 mg/kg |
| Topics | 5-MeO-DMT DMT |
| Citations | 6 |
| Key findings | 5-methoxy-N,N-dimethyltryptamine prolonged the latency and duration of post-decapitation convulsions in rats, an effect partially blocked by methergoline. |
Abstract
The effect of acute administration of rats with the 5-hydroxytryptamine (5-HT) agonist drug 5-methoxy-N,N-dimethyltryptamine on the convulsions released by decapitation was examined. The postsynaptic agonist, 5-methoxy-N,N-dimethyltryptamine, prolonged the latency and duration from the 0.5 mg/kg dose upwards. Methergoline, 2.0 mg/kg intraperitoneally injected immediately prior to 5-methoxy-N,N-dimethyltryptamine, caused some considerable blockade of the effects of the 5-HT agonist on post-decapitation convulsions (PDG's). Long-term p-chloroamphetamine (2x10 mg/kg) and p-chlorophenylalanine (1 x 300 mg/kg) did not antagonise the 5-methoxy-N-N-dimethyltryptamine induced changes of PDC's but, by themselves, prolonged PDC duration. The utility of the 5-methoxy-N,N-dimethyltryptamine-PDC method for studying 5-HT receptor mechanisms may be worth considering.