Further studies on the dose-dependent stimulus properties of 5-methoxy-N,N-dimethyltryptamine.
R Young, John A. Rosecrans, Richard A Glennon
Pharmacology, biochemistry, and behavior December 1, 1986 DOI: 10.1016/0091-3057(86)90113-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Sample size | 22 |
| Population | Rats |
| Interventions | 5-OMe DMT Cyproheptadine Methysergide Cinanserin Methergoline |
| Dose | 1.5 mg/kg and 3.0 mg/kg of 5-OMe DMT |
| Topics | 5-MeO-DMT DMT |
| Citations | 10 |
| Key findings | The ability of serotonin antagonists to block the 5-OMe DMT stimulus depends on the dose of 5-OMe DMT and the specific antagonist, with cyproheptadine completely blocking the low-dose stimulus but having no effect at the higher dose. |
Abstract
Twenty-two rats were trained to discriminate either 1.5 mg/kg of 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a standard two-lever operant procedure. Once responding was stable, various doses of several serotonin (5-HT) antagonists, i.e., cyproheptadine (CYP), methysergide (UML), cinanserin (CIN), and methergoline (MCE), were administered in combination with 5-OMe DMT, to assess the ability of each antagonist to attenuate each 5-OMe DMT-stimulus. The 5-OMe DMT-stimulus at 1.5 mg/kg was completely antagonized by CYP, and was partially attenuated by CIN and MCE. UML had negligible effects on 5-OMe DMT-appropriate responding. In the 3.0 mg/kg 5-OMe DMT-trained rats, UML and MCE partially blocked the 5-OMe DMT-stimulus; CYP and CIN had no significant effect on 5-OMe DMT-appropriate responding. The results suggest that until the in vivo effects and mechanism of action of 5-OMe DMT and certain 5-HT antagonists are better understood, caution is advised when conclusions are drawn from studies employing these agents.