5-Hydroxytryptamine antagonists and the 5-methoxy-N,N-dimethyltryptamine-induced changes of postdecapitation convulsions.
Pharmacology & Toxicology 1987 DOI: 10.1111/j.1600-0773.1987.tb01716.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats (implied by standard convulsion model) |
| Interventions | 5-MeODMT mianserin methergoline cinanserin methysergide pirenperone pimozide |
| Dose | 0.5 to 4.0 mg/kg 5-MeODMT, 0.25 mg/kg pirenperone, 0.5-2.0 mg/kg pimozide |
| Topics | 5-MeO-DMT DMT |
| Citations | 2 |
| Key findings | 5-MeODMT-induced changes in postdecapitation convulsions appear to be mediated via 5-HT1 receptors, as they are blocked by certain 5-HT antagonists but not by a 5-HT2 or dopamine antagonist. |
Abstract
The ability of various compounds to antagonise the 5-MeODMT induced prolongations of latency and duration of postdecapitation convulsions (PDCs) were compared. The 5-hydroxytryptamine (5-HT) receptor antagonists, mianserin, methergoline, cinanserin and methysergide antagonised the 5-MeODMT (0.5 to 4.0 mg/kg) induced prolongations of latency to onset of convulsions substantially and to a lesser extent the prolongation of duration. The efficacy of the 5-HT antagonists for blocking 5-MeODMT changes of PDCs was roughly of the order mianserin greater than cinanserin greater than methysergide greater than methergoline. Pirenperone, the 5-HT2 antagonist, and pimozide, the dopamine receptor antagonist did not antagonise the 5-MeODMT induced changes. Mianserin, methergoline, cinanserin and methysergide, by themselves, prolonged the duration of PDCs but did not affect latency. Pirenperone (0.25 mg/kg) prolonged both the latency and duration of the PDCs while pimozide (0.5-2.0 mg/kg) had no effect upon PDCs. This evidence suggests that 5-MeODMT induced changes of PDCs are mediated via 5-HT1 receptors and thus a reliable model to combine with other measures of spinal function is suggested.