Spinal and locus coeruleus noradrenergic lesions abolish the analgesic effects of 5-methoxy-N,N-dimethyltryptamine.
W Danysz, G Jonsson, B G Minor, C Post, T Archer
Behavioral and neural biology July 1, 1986 DOI: 10.1016/s0163-1047(86)90916-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Sprague-Dawley rats |
| Interventions | 6-hydroxydopamine-induced lesions 5 7-dihydroxytryptamine-induced lesions 5-methoxy-N N-dimethyltryptamine (5-MeODMT) administration |
| Topics | 5-MeO-DMT DMT |
| Citations | 6 |
| Key findings | Depletion of noradrenaline in the locus coeruleus or spinal cord completely abolished 5-MeODMT-induced analgesia, while serotonin depletion in the nucleus raphe magnus or spinal cord only attenuated it. |
Abstract
Two experiments were performed on Sprague-Dawley rats to study the effects of noradrenaline and 5-hydroxytryptamine depletion upon the antinociceptive effects of acute 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) administration. 6-Hydroxydopamine-induced lesions following microinjections to either the locus coeruleus or the spinal cord (lumbar) abolished completely 5-MeODMT-induced analgesia in the tail-flick, hot-plate, and shock titration tests whereas 5,7-dihydroxytryptamine-induced lesions of the nucleus raphe magnus and the lumbar spinal cord attenuated 5-MeODMT analgesia in the tail-flick and shock titration tests. Thus, the experiments serve to demonstrate an important interaction between descending noradrenergic and serotonergic pathways, possibly at a spinal locus.