Chronic treatment with the antidepressant desipramine consistently reduced pain relief caused by 5-MeODMT in rats across several pain tests, while chronic amitriptyline sometimes increased that pain relief. Acute antidepressant treatment raised shock thresholds in rats not given 5-MeODMT, but effects differed from chronic treatment. The findings highlight that acute and chronic antidepressant effects on pain perception are distinct.
An injection of the serotonin agonist drug 5-methoxy-N,N-dimethyltryptamine in rats lengthened both the time until and the duration of convulsions triggered by decapitation, starting at a dose of 0.5 mg/kg. Pretreatment with the serotonin antagonist methergoline (2.0 mg/kg) partially blocked these effects. Long-term administration of p-chloroamphetamine or p-chlorophenylalanine did not counteract the drug's effects but independently prolonged convulsion duration. The authors suggest the method may be useful for studying serotonin receptor mechanisms.
Chlorpromazine (CPZ) is more toxic than mescaline (MCL) to mouse cerebellum and fibroblast cells in laboratory cultures. Fibroblast cells are more sensitive than cerebellum cells to both drugs.