Introduction: Pain perception is a subjective experience influenced by individual emotional and cognitive, including attentional and cognitive processes. In this respect, trait mindfulness-as an individual's inherent tendency to remain nonelaborative, nonjudgmental aware and attentive to the present moment-may modulate electroencephalography (EEG) responses to pain stimulation and perceived...
PAIN ReportsDecember 1, 2024Saad Ahmed Moharam, Amgad Elshikh, Mohamed Abdelbadie et al.3 citations
The inappropriate management of pain after thoracotomy results in serious complications. Several adjuvants have been added to the thoracic paravertebral block (TPVB) to enhance its effects. This work aimed to evaluate the effect of adding ketamine to TPVB on thoracotomy-related acute and chronic pain. This randomized controlled double-blinded trial included 60 patients scheduled for open...
Lumbosacral radiculopathy (LR), also known as sciatica, is a common type of radiating neurologic pain involving burning, tingling, and numbness in the lower extremities. It has an estimated lifetime prevalence as high as 43%. The objective of this randomized controlled trial was to evaluate the impact of virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) on patients with LR...
Ketamine-induced dissociation and analgesia are independent and robust to general anesthesia neural circuit alterations, suggesting that ketamine can be refined into a targeted pain therapeutic. Abstract Introduction: Ketamine, an anesthetic adjunct, is routinely administered as part of a balanced general anesthetic technique. We recently showed that the acute analgesic and dissociation...
App-delivered mindfulness improved social functioning and pain catastrophizing among patients with chronic pain. Patient characteristics predicted app engagement, highlighting important considerations for clinical settings.
The advent of neuroimaging methodologies, such as functional magnetic resonance imaging (fMRI), has significantly advanced our understanding of the neurophysiological processes supporting a wide spectrum of mind-body approaches to treat pain. A promising self-regulatory practice, mindfulness meditation, reliably alleviates experimentally induced and clinical pain. Yet, the neural mechanisms...
Most current chronic pain treatment strategies have limitations in effectiveness and tolerability, and accumulating evidence points to the added benefits of rational combinations of different therapies. However, most published clinical trials of treatment combinations have involved combinations of 2 drugs, whereas very little research has been performed to characterize interactions between drug...