Clinical Neurophysiology
October 1, 2021
Shubham Chamadia, Jacob Gitlin, Jennifer Mekonnen et al.
Objective: Ketamine is an anesthetic drug associated with dissociation. Decreased electroencephalogram alpha (8 to 13 Hz) and low-beta (13 to 20 Hz) oscillation power have been associated with ketamine-induced dissociation. We aimed to characterize surface electroencephalogram signatures that may serve as biomarkers for dissociation. Methods: We analyzed data from a single-site, open-label,...
PLoS Computational Biology
August 18, 2021
Sourish Chakravarty, Indie C. Garwood, S. Chakravarty et al.
32 citations
Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes high power gamma (25-50 Hz) oscillations alternating with slow-delta (0.1-4 Hz) oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human primates (NHPs) and electroencephalogram (EEG) recordings from human subjects. However, a detailed...
PAIN Reports
June 3, 2021
Eunice Y. Hahm, Shubham Chamadia, J. Locascio et al.
6 citations
Ketamine-induced dissociation and analgesia are independent and robust to general anesthesia neural circuit alterations, suggesting that ketamine can be refined into a targeted pain therapeutic. Abstract Introduction: Ketamine, an anesthetic adjunct, is routinely administered as part of a balanced general anesthetic technique. We recently showed that the acute analgesic and dissociation...
medRxiv
November 16, 2020
Indie C. Garwood, S. Chakravarty, Jacob Donoghue et al.
preprint
Abstract Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes bursts of 30-50 Hz oscillations alternating with 0.1 to 10 Hz oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human primates (NHPs) and electroencephalogram (EEG) recordings from human subjects. However, a detailed...
Anesthesiology
September 4, 2020
Jacob Gitlin, Shubham Chamadia, J. Locascio et al.
48 citations
Background: Ketamine is a dissociative anesthetic with analgesic properties. Ketamine’s analgesic properties have been suggested to result from its dissociative properties. To the authors’ knowledge, this postulate is unsubstantiated. The authors hypothesize that the dissociative and analgesic properties of ketamine are independent. Methods: The authors conducted a single-site, open-label study...