Interactions between analgesic drug therapy and mindfulness-based interventions for chronic pain in adults: protocol for a systematic scoping review.
Rex Park, Mohammed Mohiuddin, Patricia A Poulin, Tim V Salomons, Robert R Edwards, Howard J Nathan, Chris Haley, Ian Gilron
PAIN Reports 2019 DOI: 10.1097/pr9.0000000000000793 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review protocol Randomized Peer reviewed |
|---|---|
| Population | Adults with chronic pain, as studied in randomized controlled trials of mindfulness-based interventions |
| Intervention | Mindfulness-based interventions (MBIs) |
| Topics | Meditation |
| Keywords | Analgesic therapy Chronic pain Clinical trials Systematic review |
| Key findings | The authors propose a systematic review to assess how mindfulness-based interventions interact with concomitant analgesic drug therapies in chronic pain trials, focusing on which medications were allowed, how trials controlled for and analyzed them, and what interaction results exist. They expect the findings to help inform rational integration of MBIs with drug therapy. |
Abstract
Most current chronic pain treatment strategies have limitations in effectiveness and tolerability, and accumulating evidence points to the added benefits of rational combinations of different therapies. However, most published clinical trials of treatment combinations have involved combinations of 2 drugs, whereas very little research has been performed to characterize interactions between drug and nondrug interventions. Mindfulness-based interventions (MBIs) have been emerging as a safe and potentially effective treatment option in the management of chronic pain, but it is unclear how MBIs can and should be integrated with various other pain treatment interventions. Thus, we seek to review available clinical trials of MBIs for chronic pain to evaluate available evidence on the interactions between MBIs and various pharmacological treatments. A detailed search of trials of MBIs for the treatment of chronic pain in adults will be conducted on the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and PsycINFO from their inception until the date the searches are run to identify relevant randomized controlled trials. Primary outcomes will include the following: (1) what concomitant analgesic drug therapies (CADTs) were allowed; (2) if and how trials controlled for CADTs and analyzed their interaction; and (3) results of available analyses of interactions between the MBI and CADT. This review is expected to synthesize available evidence describing the interactions between MBIs and various studied drug therapies for chronic pain. Available evidence may help inform the rational integration of MBIs with drug therapy for chronic pain.
Comparable studies
Other systematic reviews and meta-analyses on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Meditation Programs for Psychological Stress and Well-being Diverse adult clinical populations | 2014 | Meta-analysis | n = 3,515 |
| Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis Healthy subjects | 2009 | Systematic review and meta-analysis | |
| The psychological effects of meditation: A meta-analysis. Nonclinical groups of adult meditators | 2012 | Meta-analysis | n = 163 |
| Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse Adults with recurrent depression in full or partial remission | 2016 | Meta-analysis of individual patient data from randomized controlled trials | n = 1,258 |
| Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials | 2011 | Systematic review |
Citations in the library
Cites 14
- Mindfulness: A proposed operational definition. Clinical Psychology Science and Practice 2004
- Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioural therapy for the treatment and management of chronic pain: A systematic review and network meta-analysis Evidence-Based Mental Health January 23, 2019
- Mindfulness-based interventions for chronic pain: Evidence and applications. Asian Journal of Psychiatry February 2018
- Randomized Trial of the Effect of Mindfulness-Based Stress Reduction on Pain-Related Disability, Pain Intensity, Health-Related Quality of Life, and A1C in Patients With Painful Diabetic Peripheral Neuropathy. Clinical diabetes : a publication of the American Diabetes Association December 2017
- Dispositional Mindfulness and Psychological Health: a Systematic Review Mindfulness July 1, 2017
and 9 more in the library