International Immunopharmacology
September 22, 2026
Hanxuan Wang, Yu Huang, Qingwen Hu et al.
Schizophrenia (SCZ) is a serious neuropsychiatric disorder with a complex etiology. Neuroinflammation has received much attention as a crucial contributor to the pathogenesis of SCZ. S-propargyl-L-cysteine (SPRC), a synthesized analog of S-allyl-L-cysteine, increases endogenous hydrogen sulfide (H2S) synthesis and exerts potent antioxidative and anti-inflammatory effects. However, its potential...
PAIN Reports
October 7, 2025
Chen Lu, Nele Berner, Lena Hagel et al.
Introduction: Pain perception is a subjective experience influenced by individual emotional and cognitive, including attentional and cognitive processes. In this respect, trait mindfulness-as an individual's inherent tendency to remain nonelaborative, nonjudgmental aware and attentive to the present moment-may modulate electroencephalography (EEG) responses to pain stimulation and perceived...
National Science Review
September 5, 2025
Huoqing Luo, Ming Chen, Yingjie Ning et al.
1 citation
-methyl-d-aspartate receptor (NMDAR) blockade is crucial for the rapid antidepressant effects of ketamine, the involvement of other mechanisms remains contentious, particularly regarding the role of serotonin, a key neurotransmitter in the target of traditional antidepressants. Here, we demonstrate that ketamine elevates serotonin levels by inhibiting the serotonin transporter (SERT). A...
Religions
August 30, 2025
Chen Lu
Jñānakīrti (Tib. Ye shes grags pa), an eminent monk of the late Indian Buddhist period, composed the Tattvāvātara (De kho na nyid la ’jug pa, Realizing Reality), of which only a Tibetan translation exists in the Tibetan Tripiṭaka-Tanjur. The treatise is considered an exposition of the Mahāmudrā teachings, with the chapter entitled “Practices of the Secret Mantra Approach” (gSang sngags kyi...
Frontiers in Pain Research
April 1, 2025
Chen Lu, Nele Berner, Lena Hagel et al.
IntroductionPain habituation, the reduction in response to repeated painful stimuli, is a positive adaptation process, while pain sensitization is linked to chronic pain. Traits like mindfulness and extraversion affect pain processing, but their influence on pain adaptation and potential interactions remains underexplored. This study aimed to examine the relationship between trait mindfulness,...
Frontiers in Neuroscience
2023
Chen Lu, Vera Moliadze, Frauke Nees
13 citations
Mindfulness-based processes have been shown to enhance attention and related behavioral responses, including analgesia, which is discussed as an effective method in the context of pain interventions. In the present review, we introduce the construct of mindfulness, delineating the concepts, factors, and processes that are summarized under this term and might serve as relevant components of the...