-methyl-d-aspartate receptor (NMDAR) blockade is crucial for the rapid antidepressant effects of ketamine, the involvement of other mechanisms remains contentious, particularly regarding the role of serotonin, a key neurotransmitter in the target of traditional antidepressants. Here, we demonstrate that ketamine elevates serotonin levels by inhibiting the serotonin transporter (SERT). A...
Jñānakīrti (Tib. Ye shes grags pa), an eminent monk of the late Indian Buddhist period, composed the Tattvāvātara (De kho na nyid la ’jug pa, Realizing Reality), of which only a Tibetan translation exists in the Tibetan Tripiṭaka-Tanjur. The treatise is considered an exposition of the Mahāmudrā teachings, with the chapter entitled “Practices of the Secret Mantra Approach” (gSang sngags kyi...
Mindfulness-based processes have been shown to enhance attention and related behavioral responses, including analgesia, which is discussed as an effective method in the context of pain interventions. In the present review, we introduce the construct of mindfulness, delineating the concepts, factors, and processes that are summarized under this term and might serve as relevant components of the...