Schizophrenia Bulletin
December 7, 2020
Ilvana Dzafic, Kit Melissa Larsen, Hayley Darke et al.
26 citations
Recent theories in computational psychiatry propose that unusual perceptual experiences and delusional beliefs may emerge as a consequence of aberrant inference and disruptions in sensory learning. The current study investigates these theories and examines the alterations that are specific to schizophrenia spectrum disorders vs those that occur as psychotic phenomena intensify, regardless of...
Schizophrenia Bulletin
August 5, 2020
Pantelis Leptourgos, Martin Fortier-Davy, Robin Carhart-Harris et al.
88 citations
Abstract The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory...
Schizophrenia Bulletin
June 19, 2020
Ben Alderson-Day, Angela Woods, Peter Moseley et al.
59 citations
Recent therapeutic approaches to auditory verbal hallucinations (AVH) exploit the person-like qualities of voices. Little is known, however, about how, why, and when AVH become personified. We aimed to investigate personification in individuals' early voice-hearing experiences. We invited Early Intervention in Psychosis (EIP) service users aged 16-65 to participate in a semistructured interview...
Schizophrenia Bulletin
October 8, 2019
Julian Rössler, Wulf Rössler, Erich Seifritz et al.
16 citations
Dopamine is involved in the pathophysiology of schizophrenia. Disrupted salience processing by the salience network (SN) may be a central link between dysregulated dopamine function and psychotic symptoms. However, dopaminergic influence on the SN and its presumed influence on psychotic and subpsychotic symptoms or psychotic-like experiences in healthy individuals remain unclear. Therefore, we...
Schizophrenia Bulletin
August 8, 2018
Tanya M Luhrmann, Ben Alderson-Day, Vaughan Bell et al.
74 citations
That trauma can play a significant role in the onset and maintenance of voice-hearing is one of the most striking and important developments in the recent study of psychosis. Yet the finding that trauma increases the risk for hallucination and for psychosis is quite different from the claim that trauma is necessary for either to occur. Trauma is often but not always associated with...
Schizophrenia Bulletin
March 14, 2017
Georg Northoff, Paola Magioncalda, Matteo Martino et al.
95 citations
Time is an essential feature in bipolar disorder (BP). Manic and depressed BP patients perceive the speed of time as either too fast or too slow. The present article combines theoretical and empirical approaches to integrate phenomenological, psychological, and neuroscientific accounts of abnormal time perception in BP. Phenomenology distinguishes between perception of inner time, ie,...
Schizophrenia Bulletin
October 12, 2016
Andrea Raballo
22 citations
The very presence of hallucinations raises puzzling and fascinating questions about reality … However, my real questioning did not fully occur until the voices started, which was once again a gradual process … When the voices occurred, I perceived them as omnipotent and omniscient … To me, auditory-verbal hallucinations are the result of thought processes of which I am unaware. Humpston 2014...
Schizophrenia Bulletin
June 8, 2016
Ben Alderson-Day, Kelly Diederen, Charles Fernyhough et al.
134 citations
In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International...
Schizophrenia Bulletin
December 18, 2015
Filip Španiel, Jaroslav Tintěra, Jan Rydlo et al.
55 citations
BACKGROUND: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. AIMS: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). METHOD: A functional magnetic resonance imaging (fMRI) using motor task...
Schizophrenia Bulletin
July 28, 2015
Jeffrey D. Robinson, Nils-Frederic Wagner, Georg Northoff
47 citations
Schizophrenia is a disturbance of the self, of which the attribution of agency is a major component. In this article, we review current theories of the Sense of Agency, their relevance to schizophrenia, and propose a novel framework for future research. We explore some of the models of agency, in which both bottom-up and top-down processes are implicated in the genesis of agency. We further...
Schizophrenia Bulletin
2015
Georg Northoff
Schizophrenia is a multifaceted disorder with various symptoms including auditory hallucinations, egodisturbances, passivity phenomena, and delusions. Recent neurobiological approaches have focused on, especially, the abnormal contents of consciousness, the "substantive parts" as James said, to associate them with the neural mechanisms related to sensory, motor, and cognitive functions, and the...
Schizophrenia Bulletin
October 6, 2012
Robin Carhart-Harris, Robert Leech, David Erritzøe et al.
267 citations
Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in 2 task-free resting-state scans. Primary analyses focused on...
Schizophrenia Bulletin
September 1, 2012
Bita Moghaddam, John H. Krystal
Here, we describe our collaborative efforts to use N-methyl-d-aspartate (NMDA) receptor antagonists as a translational tool to advance our understanding of the pathophysiology of schizophrenia and identify potential new targets for treatment of schizophrenia. We began these efforts in the late 1980s with a keen sense that, in both human and animal studies, we needed to move beyond the dopamine...
Schizophrenia Bulletin
September 1, 2012
Daniel C Javitt, Stephen R Zukin, Uriel Heresco-Levy et al.
Over the last 20 years, glutamatergic models of schizophrenia have become increasingly accepted as etiopathological models of schizophrenia, based on the observation that phencyclidine (PCP) induces a schizophrenia-like psychosis by blocking neurotransmission at N-methyl-D-aspartate (NMDA)-type glutamate receptors. This article reviews developments in two key predictions of the model: first,...
Schizophrenia Bulletin
September 1, 2012
Edward F. Domino, Elliot D. Luby
The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology...
Schizophrenia Bulletin
October 7, 2010
Irwin Feinberg
47 citations
In 1978,1 a new neuroscience-based model of hallucinations was proposed in this journal. The premise of this model was that hallucinatory experiences are necessarily produced by self-generated neural activity. Their pathology does not lie in the fact that they are self-generated. Much, if not most, of our mental experience results from endogenous or “spontaneous” neural activity. Hallucinations...
Schizophrenia Bulletin
November 1, 2008
Cécile Henquet, Marta Di Forti, Paul D. Morrison et al.
Cannabis use is considered a contributory cause of schizophrenia and psychotic illness. However, only a small proportion of cannabis users develop psychosis. This can partly be explained by the amount and duration of the consumption of cannabis and by its strength but also by the age at which individuals are first exposed to cannabis. Genetic factors, in particular, are likely to play a role in...
Schizophrenia Bulletin
August 12, 2006
Mark van der Gaag
128 citations
This selective review combines cognitive models and biological models of psychosis into a tentative integrated neuropsychiatric model. The aim of the model is to understand better, how pharmacotherapy and cognitive-behavior therapy come forward as partners in the treatment of psychosis and play complementary and mutually reinforcing roles. The article reviews the dominant models in literature....
Schizophrenia Bulletin
1993
R E Hoffman, T H McGlashan
Computer simulations of parallel distributed processing (PDP) neural networks have increased our understanding of brain functioning. This article reviews how PDP concepts can contribute to our understanding of schizophrenic symptoms. Psychotic states induced by phencyclidine and the adult form of metachromatic leukodystrophy, as well as neurometabolic studies, suggest that schizophrenia...
Schizophrenia Bulletin
1987
Roderick Anscombe
225 citations
The schizophrenic experience is described as an inability to sustain an intentional focus to attention. Attention is captured by incidental details in the schizophrenic patient's environment, and this gives rise to a spurious sense of significance. The patient's inability to direct a train of thought prevents full access to long-term memory so that early components of perception, which are...
Schizophrenia Bulletin
1983
Lawrence Fischman
109 citations
Many observers have noted similarities between dreams, hallucinogenic drug states, and schizophrenia. In the present article, certain fundamental areas of convergence between the three states are described. Consideration is given to the hallucinogenic drug model of psychosis: the reasons for its initial attractiveness, and the reasons for its current disfavor. The concept of ego boundaries is...
Schizophrenia Bulletin
1981
P. Buckley
70 citations
Autobiographical accounts of acute mystical experience and schizophrenia are compared in order to examine the similarities between the two states. The appearance of a powerful sense of noesis, heightening of perception, feelings of communion with the "divine," and exultation may be common to both. The disruption of thought seen in the acute psychoses is not a component of the accounts of...
Schizophrenia Bulletin
1980
Loren J. Chapman, Jean P. Chapman
254 citations
Although psychotic symptoms are usually viewed as dichotomous events, both patients and nonpatients often report isolated psychotic experiences as well as psychotic-like experiences, the latter being attenuated versions of psychotic experiences. College students, previously identified as probably at high risk for psychosis, were interviewed using a modified Schedule for Affecting Disorders and...
Schizophrenia Bulletin
1978
Gordon Claridge
59 citations
Some of the difficulties of trying to establish an animal model of schizophrenia are first considered. Then, after a review of the evidence on the experimental psychopathology of schizophrenia, particularly that concerned with attention and arousal, it is concluded that the core feature which needs to be modeled in animals is some aspect of "input dysfunction." It is argued that, of the...
Schizophrenia Bulletin
1977
Joel E. Kleinman, J. Christian Gillin, Richard Jed Wyatt
20 citations
Over the years there have been many reviews of the phenomenology of hallucinogens and schizophrenia. The vast majority of these have been written by scientists who interviewed research subjects and subsequently extracted and summarized the experiences of these subjects. Comparisons of schizophrenia with drug-induced experiences have proven useful in directing further research aimed at...