Brain : a journal of neurology
May 13, 2025
Veith Weilnhammer, Marcus Rothkirch, Deniz Yilmaz et al.
11 citations
Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants,...
Neuroscience of Consciousness
2025
Katrin Reichenbach, Marcus Rothkirch, Lucca Jaeckel et al.
The signals registered by our senses are inherently ambiguous. Subjective experience, by contrast, is informative: it portrays one's interpretation of the sensory environment at a time while discarding competing alternatives. This is exemplified by bistable perception, where ambiguous sensory information induces prolonged intervals of alternating unambiguous perceptual states. According to...
Schizophrenia Bulletin
July 21, 2023
Predrag Petrović, Philipp Sterzer
42 citations
BACKGROUND AND HYPOTHESIS: The neurocomputational framework of predictive processing (PP) provides a promising approach to explaining delusions, a key symptom of psychotic disorders. According to PP, the brain makes inferences about the world by weighing prior beliefs against the available sensory data. Mismatches between prior beliefs and sensory data result in prediction errors that may...
Philosophy and the Mind Sciences
April 19, 2022
Joshua M. Martin, Philipp Sterzer
7 citations
In Philosophy of Psychedelics, Letheby provides a convincing basis for the idea that psychedelics primarily derive their therapeutic potential through mediating favourable changes to self-related belief systems. In this commentary, we take a closer look at the role that contextual factors (‘set’ and ‘setting’) play in Letheby’s two-factor account of psychedelic therapy. While Letheby...
Current biology : CB
July 12, 2021
Veith Weilnhammer, Merve Fritsch, Meera Chikermane et al.
In the search for the neural correlates of consciousness, it has remained controversial whether prefrontal cortex determines what is consciously experienced or, alternatively, serves only complementary functions, such as introspection or action. Here, we provide converging evidence from computational modeling and two functional magnetic resonance imaging experiments that indicated a key role of...
Frontiers in Psychology
April 8, 2021
Heiner Stuke, Elisabeth Kress, Veith Weilnhammer et al.
41 citations
According to the predictive coding theory of psychosis, hallucinations and delusions are explained by an overweighing of high-level prior expectations relative to sensory information that leads to false perceptions of meaningful signals. However, it is currently unclear whether the hypothesized overweighing of priors (1) represents a pervasive alteration that extends to the visual modality and...
Consciousness and Cognition
August 1, 2019
Jakob Kaminski, Philipp Sterzer, Aaron Mishara
We present a schizophrenia patient who reports "seeing rain" with attendant somatosensory features which separate him from his surroundings. Because visual/multimodal hallucinations are understudied in schizophrenia, we examine a case history to determine the role of these hallucinations in self-disturbances (Ichstörungen). Developed by the early Heidelberg School, self-disturbances comprise...
Biol Psychiatry
May 25, 2018
Philipp Sterzer, Rick A. Adams, Paul Fletcher et al.
901 citations
Fueled by developments in computational neuroscience, there has been increasing interest in the underlying neurocomputational mechanisms of psychosis. One successful approach involves predictive coding and Bayesian inference. Here, inferences regarding the current state of the world are made by combining prior beliefs with incoming sensory signals. Mismatches between prior beliefs and incoming...
Neuroimage
May 1, 2018
Gregor Wilbertz, Madhura Ketkar, Matthias Guggenmos et al.
The phenomenon of bistable perception, in which perception alternates spontaneously despite constant sensory stimulation, has been particularly useful in probing the neural bases of conscious perception. The study of such bistability requires access to the observer's perceptual dynamics, which is usually achieved via active report. This report, however, constitutes a confounding factor in the...
Frontiers in Human Neuroscience
December 22, 2016
Philipp Sterzer, Aaron Mishara, Martin Voss et al.
78 citations
Current theories in the framework of hierarchical predictive coding propose that positive symptoms of schizophrenia, such as delusions and hallucinations, arise from an alteration in Bayesian inference, the term inference referring to a process by which learned predictions are used to infer probable causes of sensory data. However, for one particularly striking and frequent symptom of...