Novel neoclerodane diterpene derivatives from the smoke of salvinorin A.
Tetrahedron Letters September 29, 2010 Zhongze Ma, Gang Deng, David Y W Lee 11 citations
Salvinorin A is a naturally-occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by spectroscopic methods. The major structural changes include epimerizations, eliminations, and...