Novel neoclerodane diterpene derivatives from the smoke of salvinorin A.
Zhongze Ma, Gang Deng, David Y W Lee
Tetrahedron Letters September 29, 2010 DOI: 10.1016/j.tetlet.2010.07.144 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Intervention | smoking salvinorin A |
| Topics | Salvia divinorum |
| Keywords | Hallucinogen Psychoactive substance Combustion chemistry Pyrolysis Smoke chemistry Thermal degradation Chemical transformations Structural changes Epimerizations Rearrangements Novel compounds Neoclerodane diterpenes Diterpene derivatives New compounds Combustion products |
| Citations | 11 |
| Key points | Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, with structural changes including epimerizations, eliminations, and rearrangements. |
Abstract
Salvinorin A is a naturally-occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by spectroscopic methods. The major structural changes include epimerizations, eliminations, and rearrangements.