Influence of LSD-25 on optically evoked potentials in the nonanesthetized rabbit
American Journal of Physiology-Legacy Content June 1, 1959 DOI: 10.1152/ajplegacy.1959.196.6.1181 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Chronically prepared unanesthetized and noncurarized rabbits |
| Intervention | LSD-25 (i.v.) |
| Dose | 35 µg/animal |
| Duration | 23-hour period |
| Topics | LSD |
| Keywords | Latency audio Rabbit cipher Anesthesia Pharmacology |
| Citations | 12 |
| Key findings | LSD-25 enhanced optically evoked cortical potentials for over six hours, reduced latency by about 10%, and greatly reduced variability of amplitude and latency for 1–3 hours after injection. |
Abstract
The influence of LSD-25 (i.v.) upon the optically evoked cortical potentials was studied in chronically prepared unanesthetized and noncurarized rabbits over a 23-hour period. With moderate doses of the drug (35 µg/animal) the potentials were enhanced for a period of over 6 hours. The time course of the amplitudes indicates a triphasic pattern. LSD-25 reduced the latency of the potentials by about 10%. LSD-25 was found to have a marked effect upon variability of both the amplitude and the latency. Both these variabilities were greatly reduced for 1–3 hours after injection.