Comprehensive Psychiatry
July 1, 2025
Luca Pellegrini, Naomi A Fineberg, Sorcha O'Connor et al.
17 citations
Obsessive-compulsive disorder (OCD) is a common and disabling condition. A large proportion of patients fail to respond to first-line treatment with serotonin reuptake inhibitors either selective serotonin reuptake inhibitors (SSRIs) or clomipramine. Preliminary evidence suggests psilocybin, a serotonin receptor agonist, might be efficacious. We conducted a pharmacological challenge study to...
Journal of Obsessive-Compulsive and Related Disorders
March 19, 2025
Rodolfo Leuzzi, Giovanni Tardivo, Luca Pellegrini et al.
3 citations
There is interest in the potential of psychedelics as treatments for Obsessive-Compulsive and Related Disorders (OCRDs), though research in this field is still at an early stage. In this review, we examine the methodological issues present in existing research investigating the use of psychedelics in OCRDs, as a basis for improved trial design. We searched PubMed and PsycInfo for published...
Cureus
January 29, 2025
Sorcha O'Connor, Kate Godfrey, Sara Reed et al.
2 citations
This study's results are expected to offer critical insights into the neural mechanisms underlying the effects of psilocybin-assisted therapy in treating OCD, and whether these correlate with changes in the cognitive features of the condition. As a secondary aim, it will ascertain whether a low, tolerable dose is a feasible and efficacious clinical treatment, and will provide crucial data to...
Cureus
2025
Sorcha O'Connor, Kate Godfrey, Sara Reed et al.
correction
Background: Obsessive-compulsive disorder (OCD) is a complex condition marked by persistent distressing thoughts and repetitive behaviours. Despite its prevalence, the mechanisms behind OCD remain elusive, and current treatments are limited. This protocol outlines an investigative study for individuals with OCD, exploring the potential of psilocybin to improve key components of cognition...