Long lasting supersensitivity to 5-HT mediated behaviour following monoamine depletion in the rat brain.
Acta Pharmacologica et Toxicologica October 1986 DOI: 10.1111/j.1600-0773.1986.tb00172.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-methoxy-N N-dimethyltryptamine reserpine alpha-methyltyrosine |
| Dose | 5-methoxy-N,N-dimethyltryptamine 1 mg/kg intraperitoneally; PCPA 2 × 200 mg/kg intraperitoneally; reserpine 5 mg/kg subcutaneously; alpha-methyltyrosine 250 + 125 mg/kg intraperitoneally |
| Duration | Responses assessed between 2 and 14 days after PCPA injections and between 1 and 42 days after a single reserpine dose |
| Topics | Serotonin |
| Key findings | Depleting brain serotonin with p-chlorophenylalanine or reserpine produced rapid, long-lasting supersensitivity of the 5-HT behavioral syndrome induced by 5-methoxy-N,N-dimethyltryptamine, with responses enhanced 2–14 days after PCPA and 1–42 days after a single reserpine dose. Catecholamine depletion with alpha-methyltyrosine had no effect, which the authors say supports using 5-HT-mediated behavioral models to study changes in 5-HT receptor activity. |
Abstract
The effects of the depletion of 5-hydroxytryptamine (5-HT) in the rat brain upon the 5-HT behavioural syndrome (ejaculatory response, abduction of hind-limbs, forepaw treading, and Straub tail) induced by 5-methoxy-N,N-dimethyltryptamine (1 mg/kg intraperitoneally) were investigated. The 5-HT depletion was produced by p-chlorophenylalanine (PCPA 2 X 200 mg/kg intraperitoneally) or by reserpine (5 mg/kg subcutaneously). It resulted in rapidly developing and long-lasting supersensitivity of the behavioural responses which were enhanced between 2 and 14 days after the PCPA injections and between 1 and 42 days after a single dose of reserpine. The depletion of catecholamines by alpha-methyltyrosine (250 + 125 mg/kg intraperitoneally) had no effect. These results underline the usefulness of the 5-HT mediated behavioural models for studies of changes in 5-HT receptor activity.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cites 2
- A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists. British Journal of Pharmacology July 1, 1981
- The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N,N-dimethyltryptamine-induced ejaculation in the rat. British Journal of Pharmacology April 1, 1986