The Toxicity of Chlorpromazine and Mescaline on Mouse Cerebellum and Fibroblast Cells in Culture*
I. F. Roubein, M. Samuelly, W Keup
Acta Pharmacologica et Toxicologica November 1, 1973 DOI: 10.1111/j.1600-0773.1973.tb01534.x (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractChlorpromazine (CPZ) is more toxic than mescaline (MCL) to mouse cerebellum and fibroblast cells in laboratory cultures. Fibroblast cells are more sensitive than cerebellum cells to both drugs.
Study at a glance
| Characteristics | In vitro study Peer reviewed |
|---|---|
| Population | Mouse cerebellum and fibroblast cells |
| Interventions | Chlorpromazine Mescaline |
| Topics | Mescaline |
| Keywords | Chlorpromazine Cerebellum Fibroblast Toxicity |
| Citations | 4 |
| Key finding | Chlorpromazine is more toxic than mescaline to both cell types, and fibroblasts are more sensitive than cerebellum cells to both drugs. |
Abstract
Abstract: The toxicity of chlorpromazine (CPZ) and mescaline (MCL) to mouse cerebellum and fibroblast cells was studied in vitro . CPZ proved to be more toxic than MCL to both tissues. Fibroblast celles are more sensitive than the cerebellum to both CPZ and MCL.