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Sci Rep

ISSN 2045-2322

37 papers in the library · 1,551 citations · publishing 2016-2026

Papers

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Comparing psychedelic and meditation experience reports with natural language processing.

Sci Rep December 16, 2025 Konsta Kallio-Mannila, Rosa Salmela, Jussi Jylkkä 2 citations

Psychedelics and meditation are known for their potential to induce personally meaningful and even transformative experiences. However, it is unclear how similar these experiences are, or how they differ from each other. This explorative study used natural language processing (NLP) methods to compare reports of personally meaningful subjective experiences facilitated by either psychedelic...

DOI: 10.1038/s41598-025-27724-0 (opens in new tab) Full text (opens in new tab)

Exploring practitioners' perceptions of health behavior changes associated with psychedelic experiences.

Sci Rep November 25, 2025 Laura C. Carvalho, Jorge Encantado, Michiel van Elk et al.

In addition to evidence supporting the use of psychedelics in treating alcohol and tobacco misuse, emerging research suggests that psychedelic experiences may also facilitate beneficial changes in other health behaviors, such as diet, exercise, and meditation. This retrospective, survey-based study explored perceived health behavior changes following psychedelic experiences, from the...

DOI: 10.1038/s41598-025-25818-3 (opens in new tab) Full text (opens in new tab)

Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults.

Sci Rep November 6, 2025 Anna O. Ermakova, Fiona Dunbar, Mathieu Seynaeve et al. 3 citations

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic tryptamine. Plants containing 5-MeO-DMT have been used throughout history, and in recent years both synthetic and toad-derived 5-MeO-DMT use is being increasingly reported in naturalistic settings as well as clinical research. However, its subjective effects are not well characterised, and no qualitative research...

DOI: 10.1038/s41598-025-22620-z (opens in new tab) Full text (opens in new tab) Ego dissolution Mystical experience 5-MEO-DMT Study Hallucinogen research +11

A dynamic framework of brain functional patterns shaped by spontaneous thoughts beyond the default mode network.

Sci Rep August 4, 2025

Cognitive functions emerge from the dynamic interplay of distributed, large-scale brain networks. Functional connectivity (FC) reflects stable brain organization and general cognitive abilities, while also capturing individual variations in transient cognitive states. Analyzing data from 1,717 participants, we show that rich and diverse spontaneous thought profiles align with distinct patterns...

DOI: 10.1038/s41598-025-10432-0 (opens in new tab) Full text (opens in new tab)

Acute effects of psilocybin on the dynamics of gaze fixations during visual aesthetic perception.

Sci Rep July 9, 2025 Stephanie Müller, Federico Cavanna, Laura De la Fuente et al. 3 citations

Serotonergic psychedelics are remarkable for their capacity to induce variable yet reproducible modifications to human consciousness. The acute effects of these compounds include perceptual alterations, predominantly in the visual domain, yet these alterations have been mostly documented only by subjective reports. We used eye-tracking to quantify the effects of low vs. high doses of psilocybin...

DOI: 10.1038/s41598-025-10206-8 (opens in new tab) Full text (opens in new tab) Psilocybin Psychedelics Hallucinogens Entheogens +13

Acceptance as a possible link between past psychedelic experiences and psychological flexibility.

Sci Rep October 16, 2024 Andreas Krabbe, Pilleriin Sikka, Jussi Jylkkä 9 citations

Increased psychological flexibility (PF) may underlie the lasting positive effects of psychedelic experiences on mental well-being. The associations between different components of PF, psychological inflexibility (PI), and well-being with psychedelic use are not well understood. We conducted a cross-sectional internet survey of participants (N = 629) with experience of classical psychedelics....

DOI: 10.1038/s41598-024-75595-8 (opens in new tab) Full text (opens in new tab) Mindfulness Psychedelics Mental health Psychological flexibility +1

Attitudes of European psychiatrists on psychedelics: a cross-sectional survey study.

Sci Rep August 12, 2024 Marija Franka Žuljević, Darko Hren, Dawid Storman et al. 9 citations

Research and public interest in psychedelic-assisted psychotherapy (PAP) are growing. This study investigated attitudes toward psychedelics among a diverse and multinational sample of psychiatrists currently working in Europe. We conducted an anonymous, web-based survey consisting of demographic information, a test of basic knowledge on psychedelics, and the previously validated 20-item...

DOI: 10.1038/s41598-024-69688-7 (opens in new tab) Full text (opens in new tab) Psychedelic therapy Mental health treatment Psychiatric research Clinical trials +1

Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey.

Sci Rep August 17, 2023 Anne Buot, Cecile Pallares, Alina Oganesyan et al. 28 citations

A renewed interest in the use of psychedelics for treating obsessive compulsive disorder (OCD) has emerged in the last 20 years. But pre-clinical and clinical evidence remain scarce, and little is known about the factor determining the magnitude and persistence of the therapeutic effect. We therefore designed a retrospective online survey to explore, in the general population using psychoactive...

DOI: 10.1038/s41598-023-39812-0 (opens in new tab) Full text (opens in new tab) Psychedelics Mental health OCD Treatment Therapeutic research +1

The difference between 'placebo group' and 'placebo control': a case study in psychedelic microdosing.

Sci Rep July 26, 2023 Balázs Szigeti, David Nutt, Robin Carhart-Harris et al. 33 citations

In medical trials, 'blinding' ensures the equal distribution of expectancy effects between treatment arms in theory; however, blinding often fails in practice. We use computational modelling to show how weak blinding, combined with positive treatment expectancy, can lead to an uneven distribution of expectancy effects. We call this 'activated expectancy bias' (AEB) and show that AEB can inflate...

DOI: 10.1038/s41598-023-34938-7 (opens in new tab) Placebo effect Expectation bias Mind-body connection Psychological impact +14