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Sci Rep

ISSN 2045-2322

37 papers in the library · 1,551 citations · publishing 2016-2026

Papers

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Retraction Note: A mechanistic model of the neural entropy increase elicited by psychedelic drugs.

Sci Rep September 15, 2022 Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al. 3 citations

s attention that there was a typo in the script used to calculate the differential entropy. Therefore, the reported entropy estimations are invalid and do not produce the expected increase in entropy when using

Author Correction: Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls.

Sci Rep July 28, 2022 Joseph M. Rootman, Maggie Kiraga, Pamela Kryskow et al. 2 citations

Author Correction: Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls.

Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis.

Sci Rep May 25, 2021 Patrick Vizeli, Isabelle Straumann, Friederike Holze et al. 54 citations

Lysergic acid diethylamide (LSD) is a classic psychedelic substance that is used recreationally and investigated in psychiatric research. There are no pharmacogenetic studies on LSD. In vitro metabolic studies indicate that several cytochrome P450 (CYP) isoforms (e.g., CYP2D6, CYP1A2, and CYP2C9) are involved in LSD metabolism, but in vivo data are scarce. The present study examined the...

Examining changes in personality following shamanic ceremonial use of ayahuasca.

Sci Rep March 23, 2021 Brandon Weiss, Joshua D. Miller, Nathan T. Carter et al. 80 citations

Abstract The present study examines the association between the ceremonial use of ayahuasca—a decoction combining the Banistereopsis caapi vine and N,N-Dimethyltryptamine-containing plants—and changes in personality traits as conceived by the Five-Factor model (FFM). We also examine the degree to which demographic characteristics, baseline personality, and acute post-ayahuasca experiences...

Neural correlates of the DMT experience assessed with multivariate EEG.

Sci Rep November 19, 2019 Christopher Timmermann, Leor Roseman, Michael Schartner et al. 325 citations

Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7...

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.

Sci Rep December 15, 2017 Selen Atasoy, Leor Roseman, Mendel Kaelen et al. 225 citations

Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective...

Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms.

Sci Rep October 13, 2017 Robin Carhart-Harris, Leor Roseman, Mark Bolstridge et al. 590 citations

Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for...