Dysregulated Brain Dynamics in a Triple-Network Saliency Model of Schizophrenia and Its Relation to Psychosis.
Biological Psychiatry January 1, 2019 Kaustubh Supekar, Weidong Cai, R. Krishnadas et al.
Dynamic interactions between the salience network and two other large-scale brain networks—the central executive network and default mode network—are reduced, less persistent, and more variable in patients with schizophrenia compared with well-matched control subjects. These aberrant network dynamics distinguish patients from controls with 78% and 80% accuracy in two independent cohorts. Crucially, the degree of disruption correlates with positive psychotic symptoms but not with negative symptoms. The findings support an aberrant saliency model of psychosis, in which dysregulated time-varying engagement of the salience network contributes to the neurobiology of schizophrenia.